About: The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness

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About: The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nitric oxide belongs to the most important factors influencing structural and functional properties of vessel wall. Both genetic and environmental factors may influence its metabolism. The aim of this study was to explore whether two common polymorphisms of endothelial nitric synthase (eNOS) may, jointly with smoking, influence the stiffness of large arteries, quantified as pulse wave velocity (PWV). One hundred ninety four subjects free of manifest atherosclerotic disease or chronic pharmacotherapy were selected from population-based postMONICA study. PWV s were measured using Sphygmocor(R) device between carotic and femoral arteries (aortic PWV) and between femoral and tibialis-posterior arteries (peripheral PWV). Two common polymorphisms, T786C and G894T, were assessed. Among current smokers, homo- or heterozygous carriers of T786C mutation showed significantly higher peripheral PWV than normal genotype carriers (14.0 vs 10.7 m/sec, p<0.002); the same applied to the carriers of G894T mutation (1 Nitric oxide belongs to the most important factors influencing structural and functional properties of vessel wall. Both genetic and environmental factors may influence its metabolism. The aim of this study was to explore whether two common polymorphisms of endothelial nitric synthase (eNOS) may, jointly with smoking, influence the stiffness of large arteries, quantified as pulse wave velocity (PWV). One hundred ninety four subjects free of manifest atherosclerotic disease or chronic pharmacotherapy were selected from population-based postMONICA study. PWV s were measured using Sphygmocor(R) device between carotic and femoral arteries (aortic PWV) and between femoral and tibialis-posterior arteries (peripheral PWV). Two common polymorphisms, T786C and G894T, were assessed. Among current smokers, homo- or heterozygous carriers of T786C mutation showed significantly higher peripheral PWV than normal genotype carriers (14.0 vs 10.7 m/sec, p<0.002); the same applied to the carriers of G894T mutation (1 (en)
Title	The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness (en)
skos:prefLabel	The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness (en)
skos:notation	RIV/00023001:_____/10:00002296!RIV11-MZ0-00023001
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR9333)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Cífková, Renata
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	264381
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/10:00002296
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	pulse wave velocity; nitric oxide synthase; T786C; G894T; polymorphism; smoking (en)
http://linked.open.../riv/klicoveSlovo	nitric oxide synthase polymorphism smoking - drinking alcohol - students of the University of South Bohemia - preventive programmes G894T T786C pulse wave velocity
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[D9B482121F03]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	The quality of secondary and primary prevention of coronary heart disease in clinical practice- EUROASPIRE III CZ study
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Cífková, Renata Filipovský, J. Mayer, O. Dolejšová, M. Pešta, M. Šimon, J.
http://linked.open...ain/vavai/riv/wos	000282054700006
issn	0862-8408
number of pages	8 (xsd:int)

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