About: May alcohol-induced increase of HDL be considered as atheroprotective?

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	It is well known that the consumption of moderate doses of alcohol leads to the increase of HDL-cholesterol (HDL-C). Atheroprotectivity of HDL particles is based primarily on their role in reverse cholesterol transport (RCT). In the study with a crossover design 13 male volunteers were studied in two different regimens: i) drinking of 36 g alcohol daily and ii) drinking only non-alcoholic beverages, to test whether alcohol-induced increase of HDL cholesterol can affect cholesterol efflux (CHE) from cell culture of labeled human macrophages. Alcohol consumption induced significant (p<0.05) increases of HDL cholesterol from 1.25?0.32 to 1.34?0.38 mmol/l and Apo A1 from 1.34?0.16 to 1.44?0.19 g/l. These changes were combined with a slight increase of cholesterol efflux from 13.8?2.15 to 14.9?1.85 % (p=0.059). There were significant correlations between individual changes of HDL-C and Apo A1 concentrations and individual changes of CHE (0.51 and 0.60, respectively). In conclusion, moderate alcohol co It is well known that the consumption of moderate doses of alcohol leads to the increase of HDL-cholesterol (HDL-C). Atheroprotectivity of HDL particles is based primarily on their role in reverse cholesterol transport (RCT). In the study with a crossover design 13 male volunteers were studied in two different regimens: i) drinking of 36 g alcohol daily and ii) drinking only non-alcoholic beverages, to test whether alcohol-induced increase of HDL cholesterol can affect cholesterol efflux (CHE) from cell culture of labeled human macrophages. Alcohol consumption induced significant (p<0.05) increases of HDL cholesterol from 1.25?0.32 to 1.34?0.38 mmol/l and Apo A1 from 1.34?0.16 to 1.44?0.19 g/l. These changes were combined with a slight increase of cholesterol efflux from 13.8?2.15 to 14.9?1.85 % (p=0.059). There were significant correlations between individual changes of HDL-C and Apo A1 concentrations and individual changes of CHE (0.51 and 0.60, respectively). In conclusion, moderate alcohol co (en)
Title	May alcohol-induced increase of HDL be considered as atheroprotective? May alcohol-induced increase of HDL be considered as atheroprotective? (en)
skos:prefLabel	May alcohol-induced increase of HDL be considered as atheroprotective? May alcohol-induced increase of HDL be considered as atheroprotective? (en)
skos:notation	RIV/00023001:_____/10:00002265!RIV11-MZ0-00023001
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR8486)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Stávek, Petr Poledne, Rudolf Suchánek, Pavel Králová Lesná, Ivana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	269955
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/10:00002265
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	reverse cholesterol transport; cholesterol efflux; lipoproteins; alcohol consumption (en)
http://linked.open.../riv/klicoveSlovo	alcohol consumption cholesterol efflux lipoproteins reverse cholesterol transport
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[3AC5CA4E4D59]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Nutrition changes and reverse cholesterol transport
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Králová Lesná, Ivana Poledne, Rudolf Suchánek, Pavel Stávek, Petr
http://linked.open...ain/vavai/riv/wos	000280363700013
issn	0862-8408
number of pages	7 (xsd:int)

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