About: Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset

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About: Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Dysfunction in circuits linking frontal cortex and basal ganglia (BG) is strongly implicated in obsessivecompulsive disorder (OCD). On MRI studies, neuropsychiatric disorders with known BG pathology have abnormally short T2 relaxation values (a putative biomarker of elevated iron) in this region. We asked if BG T2 values are abnormal in OCD. We measured volume and T2 and T1 relaxation rates in BG of 32 adults with OCD and 33 matched controls. There were no group differences in volume or T1 values in caudate, putamen, or globus pallidus (GP). The OCD group had lower T2 values (suggesting higher iron content) in the right GP, with a trend in the same direction for the left GP. This effectwas driven by patients whose OCD symptoms began fromaround adolescence to early adulthood. The results suggest a possible relationship between age of OCD onset and iron deposition in the basal ganglia. Dysfunction in circuits linking frontal cortex and basal ganglia (BG) is strongly implicated in obsessivecompulsive disorder (OCD). On MRI studies, neuropsychiatric disorders with known BG pathology have abnormally short T2 relaxation values (a putative biomarker of elevated iron) in this region. We asked if BG T2 values are abnormal in OCD. We measured volume and T2 and T1 relaxation rates in BG of 32 adults with OCD and 33 matched controls. There were no group differences in volume or T1 values in caudate, putamen, or globus pallidus (GP). The OCD group had lower T2 values (suggesting higher iron content) in the right GP, with a trend in the same direction for the left GP. This effectwas driven by patients whose OCD symptoms began fromaround adolescence to early adulthood. The results suggest a possible relationship between age of OCD onset and iron deposition in the basal ganglia. (en)
Title	Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset (en)
skos:prefLabel	Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset (en)
skos:notation	RIV/00023001:_____/10:00002192!RIV11-MZ0-00023001
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Herynek, Vít
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	248448
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/10:00002192
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	obsessive-compulsive disorder; basal ganglia; age of onset; iron; magnetic resonance imaging (en)
http://linked.open.../riv/klicoveSlovo	age of onset magnetic resonance imaging obsessive-compulsive disorder iron basal ganglia
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A24131708FD2]
http://linked.open...i/riv/nazevZdroje	Brain Imaging and Behavior
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Herynek, Vít Vymazal, J. Correia, S. Giedd, J. Greenberg, BD Hassenstab, J. Hubbard, E. Murphy, DL Yip, A.
http://linked.open...ain/vavai/riv/wos	000276652900003
issn	1931-7557
number of pages	11 (xsd:int)

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