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Description
| - Dysfunction in circuits linking frontal cortex and basal ganglia (BG) is strongly implicated in obsessivecompulsive disorder (OCD). On MRI studies, neuropsychiatric disorders with known BG pathology have abnormally short T2 relaxation values (a putative biomarker of elevated iron) in this region. We asked if BG T2 values are abnormal in OCD. We measured volume and T2 and T1 relaxation rates in BG of 32 adults with OCD and 33 matched controls. There were no group differences in volume or T1 values in caudate, putamen, or globus pallidus (GP). The OCD group had lower T2 values (suggesting higher iron content) in the right GP, with a trend in the same direction for the left GP. This effectwas driven by patients whose OCD symptoms began fromaround adolescence to early adulthood. The results suggest a possible relationship between age of OCD onset and iron deposition in the basal ganglia.
- Dysfunction in circuits linking frontal cortex and basal ganglia (BG) is strongly implicated in obsessivecompulsive disorder (OCD). On MRI studies, neuropsychiatric disorders with known BG pathology have abnormally short T2 relaxation values (a putative biomarker of elevated iron) in this region. We asked if BG T2 values are abnormal in OCD. We measured volume and T2 and T1 relaxation rates in BG of 32 adults with OCD and 33 matched controls. There were no group differences in volume or T1 values in caudate, putamen, or globus pallidus (GP). The OCD group had lower T2 values (suggesting higher iron content) in the right GP, with a trend in the same direction for the left GP. This effectwas driven by patients whose OCD symptoms began fromaround adolescence to early adulthood. The results suggest a possible relationship between age of OCD onset and iron deposition in the basal ganglia. (en)
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Title
| - Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset
- Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset (en)
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skos:prefLabel
| - Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset
- Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset (en)
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skos:notation
| - RIV/00023001:_____/10:00002192!RIV11-MZ0-00023001
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00023001:_____/10:00002192
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - obsessive-compulsive disorder; basal ganglia; age of onset; iron; magnetic resonance imaging (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Brain Imaging and Behavior
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Herynek, Vít
- Vymazal, J.
- Correia, S.
- Giedd, J.
- Greenberg, BD
- Hassenstab, J.
- Hubbard, E.
- Murphy, DL
- Yip, A.
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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