About: H-1 MR spectroscopy in histopathological subgroups of mesial temporal lobe epilepsy

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About: H-1 MR spectroscopy in histopathological subgroups of mesial temporal lobe epilepsy Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of the study was to analyze the lateralizing value of proton magnetic resonance spectroscopy (1H MRS) in histopathologically different subgroups of mesial temporal lobe epilepsies (MTLE) and to correlate results with clinical, MRI and seizure outcome data. A group of 35 patients who underwent resective epilepsy surgery was retrospectively studied. Hippocampal 1H MR spectra were evaluated. Metabolite concentrations were obtained using LCModel and NAA/Cr, NAA/Cho, NAA/ (Cr+Cho), Cho/Cr ratios and coefficients of asymmetry were calculated. MRI correctly lateralized 89% of subjects and 1H MRS 83%. MRI together with 1H MRS correctly lateralized 100% of patients. Nineteen subjects had ?classical? hippocampal sclerosis (HS), whereas the remaining 16 patients had ?mild? HS. Nineteen patients had histopathologically proven malformation of cortical development (MCD) in the temporal pole; 16 subjects had only HS. No difference in 1H MRS findings was found between patients in different histopathological The aim of the study was to analyze the lateralizing value of proton magnetic resonance spectroscopy (1H MRS) in histopathologically different subgroups of mesial temporal lobe epilepsies (MTLE) and to correlate results with clinical, MRI and seizure outcome data. A group of 35 patients who underwent resective epilepsy surgery was retrospectively studied. Hippocampal 1H MR spectra were evaluated. Metabolite concentrations were obtained using LCModel and NAA/Cr, NAA/Cho, NAA/ (Cr+Cho), Cho/Cr ratios and coefficients of asymmetry were calculated. MRI correctly lateralized 89% of subjects and 1H MRS 83%. MRI together with 1H MRS correctly lateralized 100% of patients. Nineteen subjects had ?classical? hippocampal sclerosis (HS), whereas the remaining 16 patients had ?mild? HS. Nineteen patients had histopathologically proven malformation of cortical development (MCD) in the temporal pole; 16 subjects had only HS. No difference in 1H MRS findings was found between patients in different histopathological (en)
Title	H-1 MR spectroscopy in histopathological subgroups of mesial temporal lobe epilepsy H-1 MR spectroscopy in histopathological subgroups of mesial temporal lobe epilepsy (en)
skos:prefLabel	H-1 MR spectroscopy in histopathological subgroups of mesial temporal lobe epilepsy H-1 MR spectroscopy in histopathological subgroups of mesial temporal lobe epilepsy (en)
skos:notation	RIV/00023001:_____/09:00001993!RIV10-MZ0-00023001
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP309/02/D076), P(NR8843), Z(MZ0FNM2005), Z(MZ0IKEM2005)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hájek, Milan Dezortová, Monika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	318251
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/09:00001993
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MR spectroscopy; Temporal lobe epilepsy; Hippocampus; Malformations of cortical development; Treatment outcome (en)
http://linked.open.../riv/klicoveSlovo	Temporal lobe epilepsy MR spectroscopy Hippocampus Treatment outcome Malformations of cortical development
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[321221DC17D7]
http://linked.open...i/riv/nazevZdroje	European Radiology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Refractory focal epilepsy with normal MRI finding: Analysis of etiopathogenesis and evaluation of individual preoperative diagnostic techniques Proton Magnetic Resonance Spectroscopy: Correlation with Neuropathological Findings in Patients with Mesial Temporal Lobe Epilepsy
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Krijtová, Hana Komárek, Vladimír Marusič, Petr Zámečník, J. Hájek, Milan Kršek, Pavel Dezortová, Monika Kynčl, Martin Tomášek, M.
http://linked.open...ain/vavai/riv/wos	000262579000017
http://linked.open...n/vavai/riv/zamer	Zdokonalení časné diagnostiky, prevence a léčby těžkých vrozených vývojových vad a chorob geneticky podmíněných či s genetickou dispozicí v prenatální a postnatální fázi vývoje Výzkum kardiovaskulárních nemocí, diabetu a transplantace životně důležitých orgánů
issn	0938-7994
number of pages	9 (xsd:int)

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