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rdf:type
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Description
| - Recently, the role of the FTO gene in obesity development was described in west-European, but not in oceanic, cohorts. The objective of this study was to test the hypothesis that the FTO SNP is associated with BMI in the Slavic population and to analyze if there could be sex-specific effects of the SNP on BMI, WHR and lipid parameters. We have analyzed three large population based samples consisting of the post-MONICA study (1191 males, 1368 females) and the 3PMFs study (908 females). FTO rs17817449 SNP was related to BMI in males (p = 0.014). In the females from both the post-MONICA and the 3PMFs study, FTO had no effect on BMI. Sub analysis of females from the 3PMFs study demonstrated that FTO had an effect on BMI in postmenopausal (p = 0.035) but not in premenopausal females (FSH < 40 U/L was used like marker of the premenopausal status). WHR and lipid parameters were not associated with FTO in any of the analysed groups. These results suggest that, the effect of FTO SNP rs17817449 may be at lea
- Recently, the role of the FTO gene in obesity development was described in west-European, but not in oceanic, cohorts. The objective of this study was to test the hypothesis that the FTO SNP is associated with BMI in the Slavic population and to analyze if there could be sex-specific effects of the SNP on BMI, WHR and lipid parameters. We have analyzed three large population based samples consisting of the post-MONICA study (1191 males, 1368 females) and the 3PMFs study (908 females). FTO rs17817449 SNP was related to BMI in males (p = 0.014). In the females from both the post-MONICA and the 3PMFs study, FTO had no effect on BMI. Sub analysis of females from the 3PMFs study demonstrated that FTO had an effect on BMI in postmenopausal (p = 0.035) but not in premenopausal females (FSH < 40 U/L was used like marker of the premenopausal status). WHR and lipid parameters were not associated with FTO in any of the analysed groups. These results suggest that, the effect of FTO SNP rs17817449 may be at lea (en)
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Title
| - A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies
- A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies (en)
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skos:prefLabel
| - A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies
- A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies (en)
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skos:notation
| - RIV/00023001:_____/09:00001970!RIV10-MZ0-00023001
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1M0510), V, Z(MZ0IKEM2005)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00023001:_____/09:00001970
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - FTO; BMI; polymorphism; menopausal status (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Clinical chemistry and laboratory medicine
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Adámková, Věra
- Hubáček, Jaroslav
- Lánská, Věra
- Poledne, Rudolf
- Piťha, Jan
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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