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| rdf:type
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| Description
| - Bioavailability of tacrolimus (Tac) and cyclosporine is determined by cytochrome P450IIIA and by P-glycoprotein encoded by the CYP3A4/CYP3A5 and ABCB1 genes, which have been suggested to influence acute rejection and pharmacokinetics in renal transplantation. We aimed to study these associations in haplotype models in kohort of 832 renal transplant recipients. Acute rejection was predicted by human leukocyte antigen-DR mismatches, delayed graft function, age at renal transplantation and by the [ABCB1 +1236C; +2677G; +3435T] haplotype. ABCB1 haplotypes modify the risk of acute rejection, suggesting that ABCB1 allelic arrangement is a stronger regulator of P-glycoprotein activity than single polymorphisms. The risk of acute rejection determined by ABCB1 is independent of pharmacokinetic parameters. CYP3A haplotypes control the bioavailability of Tac, but do not modify the risk of acute rejection.
- Bioavailability of tacrolimus (Tac) and cyclosporine is determined by cytochrome P450IIIA and by P-glycoprotein encoded by the CYP3A4/CYP3A5 and ABCB1 genes, which have been suggested to influence acute rejection and pharmacokinetics in renal transplantation. We aimed to study these associations in haplotype models in kohort of 832 renal transplant recipients. Acute rejection was predicted by human leukocyte antigen-DR mismatches, delayed graft function, age at renal transplantation and by the [ABCB1 +1236C; +2677G; +3435T] haplotype. ABCB1 haplotypes modify the risk of acute rejection, suggesting that ABCB1 allelic arrangement is a stronger regulator of P-glycoprotein activity than single polymorphisms. The risk of acute rejection determined by ABCB1 is independent of pharmacokinetic parameters. CYP3A haplotypes control the bioavailability of Tac, but do not modify the risk of acute rejection. (en)
- Biologická dostupnost takrolimu a cyklosporinu A je determinována cytochromem P450IIIA a glykoproteinem-P, které jsou kódovány CYP3A4/CYP3A5 a ABCB1 geny. Bylo prokázáno, že tyto geny ovlivňují biologickou dostupnost imunosupresiv a akutní rejekci u pacientů po transplantaci ledviny. Haplotypovou analýzou provedenou na souboru 832 pacientů jsme prokázali, že akutní rejekce byla predikována neshodou v lokusu HLA-DR, opožděným rozvojem funkce štěpu, věkem příjemce v době transplantace a také [ABCB1 +1236C; +2677G; +3435T] haplotypem. Z toho vyplývá, že ABCB1 hyplotypy modifikují riziko akutní rejekce nezávisle na farmakokinetických parametrech. CYP3A haplotypy ovlivňují farmakokinetické parametry takrolimu , ale nemají vztah k riziku akutní rejekce. (cs)
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| Title
| - Haplotypic Structure of ABCB1/MDR1 Gene Modifies the Risk of the Acute Allograft Rejection in Renal Transplant Recipients.
- Haplotypová struktura AMCB1/MDR1 genu modifikuje riziko akutní rejekce štěpu u příjemců transplantované ledviny. (cs)
- Haplotypic Structure of ABCB1/MDR1 Gene Modifies the Risk of the Acute Allograft Rejection in Renal Transplant Recipients. (en)
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| skos:prefLabel
| - Haplotypic Structure of ABCB1/MDR1 Gene Modifies the Risk of the Acute Allograft Rejection in Renal Transplant Recipients.
- Haplotypová struktura AMCB1/MDR1 genu modifikuje riziko akutní rejekce štěpu u příjemců transplantované ledviny. (cs)
- Haplotypic Structure of ABCB1/MDR1 Gene Modifies the Risk of the Acute Allograft Rejection in Renal Transplant Recipients. (en)
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| skos:notation
| - RIV/00023001:_____/08:00001846!RIV09-MZ0-00023001
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(NR8816), Z(MZ0IKEM2005)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00023001:_____/08:00001846
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - cyclosporine; cytochrome P450; haplotypes; renal transplantation; P-glycoprotein; pharmacogenetics; single nucleotide polymorphism; tacrolimus. (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Brabcová, Irena
- Bandúr, Štěpán
- Hřibová, Petra
- Novotná, Eva
- Petrášek, Jan
- Viklický, Ondřej
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| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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