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| Description
| - We compared the effect of rosiglitazone (RSG) in adult male rats of two genetically defined models of metabolic syndrome, the PD/Cub and BN.SHR4 rat strains, in contrast to their insulin-sensitive, normolipidemic counterpart, the Brown Norway strain. All rats were fed high-fat diet for the period of four weeks, the experimental groups received RSG (0.4mg/100g body weight) during the last two weeks of HFD-feeding. The mass and the sensitivity of visceral adipose tissue to insulin-stimulated lipogenesis increased with RSG treatment only in PD, corresponding with significant increase in expression of prostaglandin D2 synthase. The glucose tolerance was enhanced in all strains. The genes with genotype-specific expression change included aquaporin 9, ADAM metallopeptidase domain 7, catechol-O-methyl transferase and carnitine palmitoyltransferase 1B. In conclusion, RSG effects on lipid deposition and insulin sensitivity of peripheral tissues were largely dependent on the diet-modulated, pharmacogenomic i
- We compared the effect of rosiglitazone (RSG) in adult male rats of two genetically defined models of metabolic syndrome, the PD/Cub and BN.SHR4 rat strains, in contrast to their insulin-sensitive, normolipidemic counterpart, the Brown Norway strain. All rats were fed high-fat diet for the period of four weeks, the experimental groups received RSG (0.4mg/100g body weight) during the last two weeks of HFD-feeding. The mass and the sensitivity of visceral adipose tissue to insulin-stimulated lipogenesis increased with RSG treatment only in PD, corresponding with significant increase in expression of prostaglandin D2 synthase. The glucose tolerance was enhanced in all strains. The genes with genotype-specific expression change included aquaporin 9, ADAM metallopeptidase domain 7, catechol-O-methyl transferase and carnitine palmitoyltransferase 1B. In conclusion, RSG effects on lipid deposition and insulin sensitivity of peripheral tissues were largely dependent on the diet-modulated, pharmacogenomic i (en)
- Byl porovnán účinek rosiglitazonu (RSG) u dospělých samců u dvou geneticky definovaných modelů metabolického syndrome, PD/Cub a BN.SHR4 a kontrolního insulin senzitivního kmene Brown Norway. Potkani byli krmeni vysokotukovou dietou po dobu 4 týdnů, experimentální skupina dostávala RSG v dávce 0,4mg/100g tělesné hmotnosti. RGG zvyšoval senzitivitu tukové tkáně k účinku inzulinu u PD potkanů, která byla spojena se vyšší expresí prostaglandin D2 syntázy. RSG pozitivně ovlivnil glukózovou tolerance u všech srovnávaných kmenů. RSG zvýšil expresi genů pro aquaporin 9, ADAM metallopeptidázu, catechol-O-methyl transferázu and carnitine palmitoyltransferázu 1B.Vliv RSG byl závislý na farmakogenomické interakci. (cs)
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| Title
| - Pharmacogenomics of metabolic effects of rosiglitazone
- Pharmacogenomics of metabolic effects of rosiglitazone (en)
- Faramkogenomika metabolických účinků rosiglitazonu (cs)
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| skos:prefLabel
| - Pharmacogenomics of metabolic effects of rosiglitazone
- Pharmacogenomics of metabolic effects of rosiglitazone (en)
- Faramkogenomika metabolických účinků rosiglitazonu (cs)
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| skos:notation
| - RIV/00023001:_____/08:00001764!RIV09-MZ0-00023001
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(NR8495), Z(MSM0021620807)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00023001:_____/08:00001764
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Rosiglitazone; metabolic syndrome; lipogenesis; pharmacogenomic interaction (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Kazdová, Ludmila
- Oliyarnyk, Olena
- Corbeil, G.
- Hamet, P.
- Tremblay, J.
- Šedová, L.
- Šeda, Ondřej
- Křen, V.
- Křenová, D.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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