About: Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity     Goto   Sponge   NotDistinct   Permalink

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Description
  • We compared the binding affinities of the shortened and full-length insulin analogs [NMeHisB26]-DTI-NH2 and [NMeAlaB26]-DTI-NH2 with substitutions at position B26. We found that our shortened analogs, have different modes of interaction with the insulin receptor compared to natural insulin.
  • We compared the binding affinities of the shortened and full-length insulin analogs [NMeHisB26]-DTI-NH2 and [NMeAlaB26]-DTI-NH2 with substitutions at position B26. We found that our shortened analogs, have different modes of interaction with the insulin receptor compared to natural insulin. (en)
  • Zkrácená analoga inzulinu , [NMeHisB26]-DTI-NH2 and [NMeAlaB26]-DTI-NH2 mají v porovnání s normálním inzulinem odlišný způsob interakce s inzulinovým receptorem. Přes vysokou vazebnou aktivitu je metabolický účinek snížen. (cs)
Title
  • Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity
  • Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity (en)
  • Inzulinová analoga s modifikací v pozici B6. Divergence vazebné afinity a biologické aktivity. (cs)
skos:prefLabel
  • Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity
  • Insulin analogues with modifications at position B26. Divergence of binding affinity and biological activity (en)
  • Inzulinová analoga s modifikací v pozici B6. Divergence vazebné afinity a biologické aktivity. (cs)
skos:notation
  • RIV/00023001:_____/08:00001758!RIV09-MZ0-00023001
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(KJB400550702), P(LC06077), Z(AV0Z40550506), Z(MZ0IKEM2005)
http://linked.open...iv/cisloPeriodika
  • 21
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 372646
http://linked.open...ai/riv/idVysledku
  • RIV/00023001:_____/08:00001758
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • insulin; analog; binding affinity; biological activity; B26; N-methylation; glukose; adipocytes. (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [98B926CFCE64]
http://linked.open...i/riv/nazevZdroje
  • Biochemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 47
http://linked.open...iv/tvurceVysledku
  • Buděšínský, M.
  • Kazdová, Ludmila
  • Šanda, M.
  • Žáková, L.
  • Hančlová, I.
  • Jiráček, J.
  • Protivínská, E.
http://linked.open...ain/vavai/riv/wos
  • 000256043200020
http://linked.open...n/vavai/riv/zamer
issn
  • 0006-2960
number of pages
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