About: The common Y402H variant in complement factor H gene is not associated with susceptibility to myocardial infarction and its related risk factors     Goto   Sponge   NotDistinct   Permalink

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Description
  • varianta Y402H v genu; komplementární faktor H; infarkt myokardu; přidružené rizikové faktory (cs)
  • Recently, the genetic variant Y402H in the CFH (complement factor H) gene was associated with an increased risk for MI (myocardial infarction) in a prospective Caucasian cohort. In another nested case-control study, however, the CFH-Y402H variant did not carry susceptibility to MI. The aim of the present study was to test for an association between the CFH-Y402H variant and MI in a large case-control sample with a familial background for CAD (coronary artery disease). A total of 2161 individuals from the German MI family study were studied by questionnaire, physical examination and biochemical analyses. MI patients (n=1188; 51.4+/-8.6 years at first MI) were recruited from families with at least two members affected by MI and/or severe CAD. Spouses, sisters-in-law and brothers-in-law respectively, without MI/CAD were included as unaffected controls (n=973; 56.9+/-9.8 years). Genotyping was performed using a TaqMan assay. The common Y402H variant in the CFH gene was not associated with classical cardio
  • Recently, the genetic variant Y402H in the CFH (complement factor H) gene was associated with an increased risk for MI (myocardial infarction) in a prospective Caucasian cohort. In another nested case-control study, however, the CFH-Y402H variant did not carry susceptibility to MI. The aim of the present study was to test for an association between the CFH-Y402H variant and MI in a large case-control sample with a familial background for CAD (coronary artery disease). A total of 2161 individuals from the German MI family study were studied by questionnaire, physical examination and biochemical analyses. MI patients (n=1188; 51.4+/-8.6 years at first MI) were recruited from families with at least two members affected by MI and/or severe CAD. Spouses, sisters-in-law and brothers-in-law respectively, without MI/CAD were included as unaffected controls (n=973; 56.9+/-9.8 years). Genotyping was performed using a TaqMan assay. The common Y402H variant in the CFH gene was not associated with classical cardio (en)
Title
  • The common Y402H variant in complement factor H gene is not associated with susceptibility to myocardial infarction and its related risk factors
  • The common Y402H variant in complement factor H gene is not associated with susceptibility to myocardial infarction and its related risk factors (en)
  • Častá varianta Y402H v genu pro komplementární faktor H není spojena s vnímavostí k infarktu myokardu a přidruženým rizikovým faktorům (cs)
skos:prefLabel
  • The common Y402H variant in complement factor H gene is not associated with susceptibility to myocardial infarction and its related risk factors
  • The common Y402H variant in complement factor H gene is not associated with susceptibility to myocardial infarction and its related risk factors (en)
  • Častá varianta Y402H v genu pro komplementární faktor H není spojena s vnímavostí k infarktu myokardu a přidruženým rizikovým faktorům (cs)
skos:notation
  • RIV/00023001:_____/07:00001589!RIV08-MZ0-00023001
http://linked.open.../vavai/riv/strany
  • 213-218
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 414181
http://linked.open...ai/riv/idVysledku
  • RIV/00023001:_____/07:00001589
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cardiology; genetics (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [7B3F6D98CE32]
http://linked.open...i/riv/nazevZdroje
  • Clinical science
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 113
http://linked.open...iv/tvurceVysledku
  • Sedláček, Kamil
  • Stark, K.
  • Neureuther, K.
issn
  • 0143-5221
number of pages
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