About: Delayed administration of FK 506 is sufficient to suppress acute rejection changes after aortal transplantation in rats

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About: Delayed administration of FK 506 is sufficient to suppress acute rejection changes after aortal transplantation in rats Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Arterial allografts are used nowadays as a modality in the treatment of vascular prosthesis infections. Prolonged administration of immunosuppressive drugs seemed to be essential for long time patency rates of alloarterial vascular reconstructions. Nevertheless, the use of immunosuppressives if there exists an acute infection is controversial. The experimental work described herein studied effects of a delayed low-dose FK 506 administration on the development of acute rejection changes 30 days after aortal transplantation in rats. The response of the recipient's immune system to aortal wall antigens of the donor in the field of no immunosuppression resulted in an intimal proliferation and its infiltration by immunocompetent cells of the recipient, necrosis of medial smooth muscle cells, including deposition of immunoglobulines, and a massive adventitial infiltration of CD4 and CD8 positive cells. On the other hand, all the principal histological signs of rejection listed above were suppressed by Arterial allografts are used nowadays as a modality in the treatment of vascular prosthesis infections. Prolonged administration of immunosuppressive drugs seemed to be essential for long time patency rates of alloarterial vascular reconstructions. Nevertheless, the use of immunosuppressives if there exists an acute infection is controversial. The experimental work described herein studied effects of a delayed low-dose FK 506 administration on the development of acute rejection changes 30 days after aortal transplantation in rats. The response of the recipient's immune system to aortal wall antigens of the donor in the field of no immunosuppression resulted in an intimal proliferation and its infiltration by immunocompetent cells of the recipient, necrosis of medial smooth muscle cells, including deposition of immunoglobulines, and a massive adventitial infiltration of CD4 and CD8 positive cells. On the other hand, all the principal histological signs of rejection listed above were suppressed by (en) aortální štěpy, FK 506, potkany, transplantace (cs)
Title	Delayed administration of FK 506 is sufficient to suppress acute rejection changes after aortal transplantation in rats Delayed administration of FK 506 is sufficient to suppress acute rejection changes after aortal transplantation in rats (en) Opožděné podávání FK 506 je dostatečné k potlačení akutních rejekčních změn po transplantaci aorty u potkanů. (cs)
skos:prefLabel	Delayed administration of FK 506 is sufficient to suppress acute rejection changes after aortal transplantation in rats Delayed administration of FK 506 is sufficient to suppress acute rejection changes after aortal transplantation in rats (en) Opožděné podávání FK 506 je dostatečné k potlačení akutních rejekčních změn po transplantaci aorty u potkanů. (cs)
skos:notation	RIV/00023001:_____/07:00000798!RIV08-MZ0-00023001
http://linked.open.../vavai/riv/strany	371-380
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR7965)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Lodererová, Alena Adamec, Miloš Matia, Ivan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	416111
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/07:00000798
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	aortal grafts; FK 506; rats; transplantation (en)
http://linked.open.../riv/klicoveSlovo	transplantation rats FK 506 aortal grafts
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[FC1219B32602]
http://linked.open...i/riv/nazevZdroje	Transplant international
http://linked.open...in/vavai/riv/obor	FJ
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Fresh arterial allograft in vascular surgery
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Adamec, Miloš Lodererová, Alena Matia, Ivan
issn	0934-0874
number of pages	10 (xsd:int)

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