About: Genetic variability of major inflammatory mediators has no impact on the outcome of kidney transplantation     Goto   Sponge   NotDistinct   Permalink

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Description
  • Functionally relevant polymorphisms in genes of the Th1 and Th2-inflammatory pathway influence the outcome of kidney transplantation. Because these findings have not been validated, we sought confirmatory evidence of these associations in a larger group of renal transplant recipients.The effects of these polymorphisms on the incidence of AR, SR, CAN and graft survival were analyzed in single locus and haplotype models. In contrast to previous allelic association studies, neither of the polymorphisms has been associated with the outcome of kidney. Our findings reinforce the need for more rigorous research compliant with the currently accepted standards for polymorphism-disease association studies.
  • Functionally relevant polymorphisms in genes of the Th1 and Th2-inflammatory pathway influence the outcome of kidney transplantation. Because these findings have not been validated, we sought confirmatory evidence of these associations in a larger group of renal transplant recipients.The effects of these polymorphisms on the incidence of AR, SR, CAN and graft survival were analyzed in single locus and haplotype models. In contrast to previous allelic association studies, neither of the polymorphisms has been associated with the outcome of kidney. Our findings reinforce the need for more rigorous research compliant with the currently accepted standards for polymorphism-disease association studies. (en)
  • Funkční polymorfizmy v genech Th1 a Th2 zánětlivé odpovědi mohou ovlivňovat osud transplantované ledviny. Tento závěr však nebyl potvrzen a proto tato studie sledovala efekt polymorfizmů ve větší skupině příjemců transplantované ledviny. Vliv sledovaných polymorfizmů na výskyt AR, SR, CAN a přežití štěpu byl analyzován jedno - lokusovou i haplotypovou metodou. Na rozdíl od některých starších alelických asociačních studií nebyla nalezena žádná asociace mezi sledovanými polymorfizmy a osudem transplantované ledviny. Tento výsledek poukazuje na nezbytnost dalších precizních výzkumů připravených na základě v současnosti přijímaných norem pro alelické asociační studie. (cs)
Title
  • Genetic variability of major inflammatory mediators has no impact on the outcome of kidney transplantation
  • Genová variabilita hlavních mediátorů zánětu nemá vliv na osud transplantované ledviny (cs)
  • Genetic variability of major inflammatory mediators has no impact on the outcome of kidney transplantation (en)
skos:prefLabel
  • Genetic variability of major inflammatory mediators has no impact on the outcome of kidney transplantation
  • Genová variabilita hlavních mediátorů zánětu nemá vliv na osud transplantované ledviny (cs)
  • Genetic variability of major inflammatory mediators has no impact on the outcome of kidney transplantation (en)
skos:notation
  • RIV/00023001:_____/07:00000793!RIV08-MZ0-00023001
http://linked.open.../vavai/riv/strany
  • 1037-1044
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MZ0IKEM2005)
http://linked.open...iv/cisloPeriodika
  • 8
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 423142
http://linked.open...ai/riv/idVysledku
  • RIV/00023001:_____/07:00000793
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cytokines; gene polymorphisms; chronic allograft nephropathy; acute rejection; graft function (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [9043A1CCE0B8]
http://linked.open...i/riv/nazevZdroje
  • Transplantation
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 84
http://linked.open...iv/tvurceVysledku
  • Brabcová, Irena
  • Hřibová, Petra
  • Petrášek, Jan
  • Viklický, Ondřej
  • Bartošová, Kateřina
  • Lácha, Jiří
  • Hyklová, Kateřina
http://linked.open...n/vavai/riv/zamer
issn
  • 0041-1337
number of pages
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