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| Description
| - Introduction: Ghrelin is an endogenous hormone expressed predominantly in the stomach. Ghrelin controls growth hormone secretion and also affects the body s energy balance. We have analyzed the association of ghrelin variants with body weight changes after dietary/exercise intervention in healthy overweight females. Methods: Ghrelin variants Arg51 > Gln, Leu72 > Met and Gln90 > Leu were analyzed by PCR-RFLP in 80 overweight (BMI 31.1 +/- 3.0 kg/m2) females aged 25-55 years. Development of body weight and plasma lipids were analyzed in subgroups divided according to ghrelin genotypes. Results: Carriers of the Met72Met genotype were resistant to dietary/exercise intervention. They lost 1.5 kg compared to Leu72 carriers (5.3 kg). Other variants had no effect on body weight changes. Plasma lipids were not changed significantly between subgroups divided according to ghrelin variants. Conclusions: Common variants in ghrelin may have an effect on changes of body weight after behavior
- Introduction: Ghrelin is an endogenous hormone expressed predominantly in the stomach. Ghrelin controls growth hormone secretion and also affects the body s energy balance. We have analyzed the association of ghrelin variants with body weight changes after dietary/exercise intervention in healthy overweight females. Methods: Ghrelin variants Arg51 > Gln, Leu72 > Met and Gln90 > Leu were analyzed by PCR-RFLP in 80 overweight (BMI 31.1 +/- 3.0 kg/m2) females aged 25-55 years. Development of body weight and plasma lipids were analyzed in subgroups divided according to ghrelin genotypes. Results: Carriers of the Met72Met genotype were resistant to dietary/exercise intervention. They lost 1.5 kg compared to Leu72 carriers (5.3 kg). Other variants had no effect on body weight changes. Plasma lipids were not changed significantly between subgroups divided according to ghrelin variants. Conclusions: Common variants in ghrelin may have an effect on changes of body weight after behavior (en)
- Úvod: Ghrelin je endogenní hormon exprimovaný převážně v žaludku. Ghrelin řídí sekreci růstových hormonů a ovlivňuje i energetickou bilanci organismu. Hodnotili jsme asociaci mezi variantami genu pro ghrelin a změnami tělesné hmotnosti po úpravě stravy/po fyzické zátěžové intervenci u zdravých žen s nadváhou. Metody: Varianty genu pro ghrelin Arg51 > Gln, Leu72 > Met a Gln90 > Leu byly analyzovány technikou PCR-RFLP u 80 žen s nadváhou (BMI 31,1 +/- 3,0 kg/m2) ve věku 25-55 let. Změny tělesné hmotnosti a koncentrací plazmatických lipidů byly analyzovány v podskupinách podle genotypů pro ghrelin. Výsledky: Nositelé varianty Met72Met vykazovali rezistenci vůči úpravě stravy/fyzicky zátěžové intervenci. Jejich tělesná hmotnost se snížila o 1,5 kg ve srovnání s nositeli varianty Leu72 (5,3 kg). Ostatní varianty na změny tělesné hmotnosti vliv neměly. Hodnoty plazmatických lipidů u podskupin rozdělených podle variant genu pro ghrelin se statisticky významně nezměnily. Závěry: Běžné (cs)
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| Title
| - Effect of ghrelin variants on weight loss after dietary/excercise interventions
- Effect of ghrelin variants on weight loss after dietary/excercise interventions (en)
- Vliv variant genu pro ghrelin na úbytek tělesné hmotnosti po úpravě stravy/po zátěžové intervenci (cs)
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| skos:prefLabel
| - Effect of ghrelin variants on weight loss after dietary/excercise interventions
- Effect of ghrelin variants on weight loss after dietary/excercise interventions (en)
- Vliv variant genu pro ghrelin na úbytek tělesné hmotnosti po úpravě stravy/po zátěžové intervenci (cs)
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| skos:notation
| - RIV/00023001:_____/07:00000737!RIV08-MZ0-00023001
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00023001:_____/07:00000737
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - ghrelin; genetic polymorphism; body weight; diet; exercise (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Hubáček, Jaroslav
- Poledne, Rudolf
- Suchánek, Pavel
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