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| rdf:type
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| Description
| - Bylo analyzováno, zda varianty v genech pro transformační růstový faktor beta1 (TGF-beta1; Leu10>Pro a Arg25>Pro), inhibitor plasminogenového aktivátoru (PAI-1; 4G>5G varianta) a kolagen -1 (COL1A-1; Sp1 varianta) mohou být genetickým determinantem osteoporózy na 1400 kontrolních žen populačního souboru, na 218 postmenopausálních osteoporotických ženách a na 151 postmenopausálních ženách s vyšší kostní denzitou. Nenalezli jsme signifikantní rozdíly ve frekvencích jednotlivých alela genotypů mezi skupinami. Varianty v genech pro TGF-beta1, PAI-1 a COL1A-1 nejsou spojeny s BMI v české populaci. (cs)
- OBJECTIVE: The aim of this study was to examine whether the variants in genes for transforming growth factor beta1 (TGF-beta1; Leu10>Pro and Arg25>Pro), plasminogen activator inhibitor 1 (PAI-1; 4G>5G variant) and collagen -1 (COL1A-1; Sp1 variant) may be useful in identifying individuals with increased susceptibility to early postmenopausal bone loss within the population of Czech women. METHODS: Polymorphisms were genotyped (by PCR and restriction analysis) in 1400 females representatively selected from the Czech population as well as in 218 postmenopausal osteoporotic women 40-70 years of age (mean age 58.7 years) and a 151 control group of postmenopausal females in the same age range (mean age 59.1 years) with normal BMD. RESULTS: We have not found any statistically significant differences in the frequency of the individual genotypes or alleles of analyzed variants between the groups of osteoporotic patients (OP), population group (PG) and control group (CG). The frequencies of the indivi
- OBJECTIVE: The aim of this study was to examine whether the variants in genes for transforming growth factor beta1 (TGF-beta1; Leu10>Pro and Arg25>Pro), plasminogen activator inhibitor 1 (PAI-1; 4G>5G variant) and collagen -1 (COL1A-1; Sp1 variant) may be useful in identifying individuals with increased susceptibility to early postmenopausal bone loss within the population of Czech women. METHODS: Polymorphisms were genotyped (by PCR and restriction analysis) in 1400 females representatively selected from the Czech population as well as in 218 postmenopausal osteoporotic women 40-70 years of age (mean age 58.7 years) and a 151 control group of postmenopausal females in the same age range (mean age 59.1 years) with normal BMD. RESULTS: We have not found any statistically significant differences in the frequency of the individual genotypes or alleles of analyzed variants between the groups of osteoporotic patients (OP), population group (PG) and control group (CG). The frequencies of the indivi (en)
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| Title
| - Genetic polymorphisms of TGF-beta, PAI-1, and COL1A-1, and determination of bone mineral density in Caucasian females
- Genetic polymorphisms of TGF-beta, PAI-1, and COL1A-1, and determination of bone mineral density in Caucasian females (en)
- Genetické polymorfismy v genech pro TGF-beta, PAI-1, a COL1A-1, a determinace kostní density u bělošských žen (cs)
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| skos:prefLabel
| - Genetic polymorphisms of TGF-beta, PAI-1, and COL1A-1, and determination of bone mineral density in Caucasian females
- Genetic polymorphisms of TGF-beta, PAI-1, and COL1A-1, and determination of bone mineral density in Caucasian females (en)
- Genetické polymorfismy v genech pro TGF-beta, PAI-1, a COL1A-1, a determinace kostní density u bělošských žen (cs)
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| skos:notation
| - RIV/00023001:_____/06:00000717!RIV07-MZ0-00023001
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00023001:_____/06:00000717
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Adámková, Věra
- Hubáček, Jaroslav
- Štěpán, Jan
- Škodová, Zdenka
- Bohuslavová, Romana
- Weichetová, Markéta
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