About: Role of cholesterol 7alpha-hydroxylase (CYP7A1) in nutrigenetics and pharmacogenetics of cholesterol lowering

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About: Role of cholesterol 7alpha-hydroxylase (CYP7A1) in nutrigenetics and pharmacogenetics of cholesterol lowering Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Consistent results have been published about the A-204C promoter variant in cholesterol 7 α hydroxylase (CYP7A1) gene. CYP7A1 is a rate-limiting enzyme in the bile acid synthesis and plays an important role in keeping the cholesterol homeostasis. CYP7A1 CC homozygotes have the highest decrease of total cholesterol in response to the dietary changes in different types of dietary intervention studies. In contrast one study described that LDL-cholesterol lowering effect of statins was slightly higher in A-204A homozygotes. Consistent results have been published about the A-204C promoter variant in cholesterol 7 α hydroxylase (CYP7A1) gene. CYP7A1 is a rate-limiting enzyme in the bile acid synthesis and plays an important role in keeping the cholesterol homeostasis. CYP7A1 CC homozygotes have the highest decrease of total cholesterol in response to the dietary changes in different types of dietary intervention studies. In contrast one study described that LDL-cholesterol lowering effect of statins was slightly higher in A-204A homozygotes. (en) O A-204C variantě v promoteru genu pro cholesterol 7 α hydroxylázu (CYP7A1) byly publikovány konzistentní výsledky. CYP7A1 je klíčovým enzymem syntézy žlučových kyselin a hraje důležitou roli v udržování rovnováhy cholesterolu v organismu. CYP7A1 CC homozygoti mají nejlepší odpověď na dietně indukovanou změnu cholesterolu. Nicméně, naopak, cholesterol snižující efekt statinů je poněkud výraznější u A-204A homozygotů. (cs)
Title	Role of cholesterol 7alpha-hydroxylase (CYP7A1) in nutrigenetics and pharmacogenetics of cholesterol lowering Role of cholesterol 7alpha-hydroxylase (CYP7A1) in nutrigenetics and pharmacogenetics of cholesterol lowering (en) Cholesterol 7alfa-hydroxyláza (CYP7A1) a její role v nutrigenetice a farmakogenetice snižování cholesterolu (cs)
skos:prefLabel	Role of cholesterol 7alpha-hydroxylase (CYP7A1) in nutrigenetics and pharmacogenetics of cholesterol lowering Role of cholesterol 7alpha-hydroxylase (CYP7A1) in nutrigenetics and pharmacogenetics of cholesterol lowering (en) Cholesterol 7alfa-hydroxyláza (CYP7A1) a její role v nutrigenetice a farmakogenetice snižování cholesterolu (cs)
skos:notation	RIV/00023001:_____/06:00000666!RIV07-MSM-00023001
http://linked.open.../vavai/riv/strany	93-100
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(1M0510)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Bobková, Dagmar Hubáček, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	497865
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/06:00000666
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	metabolism; genetics; nutrition (en)
http://linked.open.../riv/klicoveSlovo	genetics metabolism nutrition
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[22DBE52875D7]
http://linked.open...i/riv/nazevZdroje	Molecular diagnosis and therapy
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for cardiovascular research
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Hubáček, Jaroslav Bobková, Dagmar
issn	1177-1062
number of pages	8 (xsd:int)

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