About: Insulin sensitivity and counter-regulatory hormones in hypothyroidism and during thyroid hormone replacement therapy

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About: Insulin sensitivity and counter-regulatory hormones in hypothyroidism and during thyroid hormone replacement therapy Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	citlivost vůči inzulinu, těžká hypotyreóza, substituční léčba hormonem štítné žlázy, euglykemický clamp (cs) We examined insulin sensitivity and secretion, together with the levels of selected glucoregulatory hormones, in 15 female patients with severe hypothyroidism (H) and during subsequent thyroid hormone replacement therapy (HRT) using the euglycaemic hyperinsulinaemic clamp technique. Insulin action, as evaluated by glucose disposal, the insulin sensitivity index, and fasting post-hepatic insulin delivery rate were established. The basal levels of insulin, C-peptide and counter-regulatory hormones were measured in basal condition. In H, glucose disposal (p-0.01), the insulin sensitivity index (p-0.01) and post-hepatic insulin delivery rate (p-0.05) were significantly lower than during HRT. No significant changes in the levels of fasting insulin and C-peptide were observed. The levels of counter-regulatory hormones in patients with H were significantly higher than during HRT (glucagon, p-0.05; epinephrine, p-0.01; cortisol, p-0.05; growth hormone, p-0.05). In H, an inverse correlation We examined insulin sensitivity and secretion, together with the levels of selected glucoregulatory hormones, in 15 female patients with severe hypothyroidism (H) and during subsequent thyroid hormone replacement therapy (HRT) using the euglycaemic hyperinsulinaemic clamp technique. Insulin action, as evaluated by glucose disposal, the insulin sensitivity index, and fasting post-hepatic insulin delivery rate were established. The basal levels of insulin, C-peptide and counter-regulatory hormones were measured in basal condition. In H, glucose disposal (p-0.01), the insulin sensitivity index (p-0.01) and post-hepatic insulin delivery rate (p-0.05) were significantly lower than during HRT. No significant changes in the levels of fasting insulin and C-peptide were observed. The levels of counter-regulatory hormones in patients with H were significantly higher than during HRT (glucagon, p-0.05; epinephrine, p-0.01; cortisol, p-0.05; growth hormone, p-0.05). In H, an inverse correlation (en)
Title	Insulin sensitivity and counter-regulatory hormones in hypothyroidism and during thyroid hormone replacement therapy Insulin sensitivity and counter-regulatory hormones in hypothyroidism and during thyroid hormone replacement therapy (en) Citlivost na inzulin a kontraregulační hormony u hypothyroiditidy a během sbustituční léčby hormonem štítné žlázy (cs)
skos:prefLabel	Insulin sensitivity and counter-regulatory hormones in hypothyroidism and during thyroid hormone replacement therapy Insulin sensitivity and counter-regulatory hormones in hypothyroidism and during thyroid hormone replacement therapy (en) Citlivost na inzulin a kontraregulační hormony u hypothyroiditidy a během sbustituční léčby hormonem štítné žlázy (cs)
skos:notation	RIV/00023001:_____/05:00001311!RIV08-MZ0-00023001
http://linked.open.../vavai/riv/strany	715-720
http://linked.open...avai/riv/aktivita	N Z
http://linked.open...avai/riv/aktivity	N, Z(MZ00000023761)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Pelikánová, Terezie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	525170
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/05:00001311
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	diabetology; endocrinology (en)
http://linked.open.../riv/klicoveSlovo	endocrinology diabetology
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[8036C924B386]
http://linked.open...i/riv/nazevZdroje	Clinical chemistry and laboratory medicine
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	43
http://linked.open...iv/tvurceVysledku	Pelikánová, Terezie Vlček, P. Hill, M. Stanická, S. Zamrazil, V. Vondra, K.
http://linked.open...n/vavai/riv/zamer	Klíčové problémy rozvoje endokrinologie a řešení metabolických poruch
issn	1434-6621
number of pages	6 (xsd:int)

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