About: Role of genetic factors in the pathogenesis of alcoholic liver disease

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About: Role of genetic factors in the pathogenesis of alcoholic liver disease Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Excessive alcohol intake leads to liver disease, which can range from simple steatosis to steatohepatitis, fi brosis, and/or cirrhosis. While steatosis develops in most regular drinkers, the vast majority do not develop more severe liver damage; the reasons for this are largelyunknown, but may include both environmental and genetic factors. Earlier data from retrospective epidemiological studies are confl icting, raising doubts over the relationship between alcohol consumption and the risk of liver disease. In contrast, recent prospective studies provide evidence for both a threshold effect and a dose-response relationship, suggesting that the minimum alcohol quantity that confers a measurable risk of developing alcoholic cirrhosis is 30 g ethanol per day and that the cumulative lifetime alcohol intake leading to cirrhosis is 100 kg of pure ethanol. In addition, men and women who consume more than 80 g/d of ethanol have an equal risk for cirrhosis. According to these data, less than 5% of heavy drin Excessive alcohol intake leads to liver disease, which can range from simple steatosis to steatohepatitis, fi brosis, and/or cirrhosis. While steatosis develops in most regular drinkers, the vast majority do not develop more severe liver damage; the reasons for this are largelyunknown, but may include both environmental and genetic factors. Earlier data from retrospective epidemiological studies are confl icting, raising doubts over the relationship between alcohol consumption and the risk of liver disease. In contrast, recent prospective studies provide evidence for both a threshold effect and a dose-response relationship, suggesting that the minimum alcohol quantity that confers a measurable risk of developing alcoholic cirrhosis is 30 g ethanol per day and that the cumulative lifetime alcohol intake leading to cirrhosis is 100 kg of pure ethanol. In addition, men and women who consume more than 80 g/d of ethanol have an equal risk for cirrhosis. According to these data, less than 5% of heavy drin (en) nemoci jater, alkohol, patogeneze (cs)
Title	Role of genetic factors in the pathogenesis of alcoholic liver disease Úloha genetických faktorů v patogenezi alkoholického onemocnění jater (cs) Role of genetic factors in the pathogenesis of alcoholic liver disease (en)
skos:prefLabel	Role of genetic factors in the pathogenesis of alcoholic liver disease Úloha genetických faktorů v patogenezi alkoholického onemocnění jater (cs) Role of genetic factors in the pathogenesis of alcoholic liver disease (en)
skos:notation	RIV/00023001:_____/04:00001076!RIV08-MZ0-00023001
http://linked.open.../vavai/riv/strany	11-12
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Špičák, Julius Šperl, Jan Petrášek, Jan Jirsa, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	584964
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/04:00001076
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	genetics; hepathology (en)
http://linked.open.../riv/klicoveSlovo	genetics hepathology
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[9E8932C89574]
http://linked.open...i/riv/nazevZdroje	World gastroenterology news
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Petrášek, Jan Špičák, Julius Jirsa, Milan Šperl, Jan Schuppan, D. Stickel, F.
issn	1567-7753
number of pages	2 (xsd:int)

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