About: Genetic background of cholesterol gallstone disease     Goto   Sponge   NotDistinct   Permalink

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  • Cholesterol gallstone formation is a multifactorial process involving a multitude of metabolic pathways. The primary pathogenic factor is hypersecretion of free cholesterol into bile. For people living in the Western Hemisphere, this is almost a normal condition, certainly in the elderly, which explains the very high incidence of gallstone disease. It is probably because the multifactorial background genes responsible for the high incidence have not yet been identified, despite the fact that genetic factors clearly play a role. Analysis of the many pathways involved in biliary cholesterol secretion reveals many potential candidates and considering the progress in unraveling the regulatory mechanisms of the responsible genes, identification of the primary gallstone genes will be successful in the near future.
  • Cholesterol gallstone formation is a multifactorial process involving a multitude of metabolic pathways. The primary pathogenic factor is hypersecretion of free cholesterol into bile. For people living in the Western Hemisphere, this is almost a normal condition, certainly in the elderly, which explains the very high incidence of gallstone disease. It is probably because the multifactorial background genes responsible for the high incidence have not yet been identified, despite the fact that genetic factors clearly play a role. Analysis of the many pathways involved in biliary cholesterol secretion reveals many potential candidates and considering the progress in unraveling the regulatory mechanisms of the responsible genes, identification of the primary gallstone genes will be successful in the near future. (en)
  • tvorba žlučových kamenů z cholesterolu, metabolické dráhy, volný cholesterol (cs)
Title
  • Genetická podstata onemocnění cholesterolových žlučových kamenů (cs)
  • Genetic background of cholesterol gallstone disease
  • Genetic background of cholesterol gallstone disease (en)
skos:prefLabel
  • Genetická podstata onemocnění cholesterolových žlučových kamenů (cs)
  • Genetic background of cholesterol gallstone disease
  • Genetic background of cholesterol gallstone disease (en)
skos:notation
  • RIV/00023001:_____/03:00001505!RIV08-MZ0-00023001
http://linked.open.../vavai/riv/strany
  • 1-19
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N
http://linked.open...iv/cisloPeriodika
  • 1
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http://linked.open...dnocenehoVysledku
  • 608133
http://linked.open...ai/riv/idVysledku
  • RIV/00023001:_____/03:00001505
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • genetics; hepatology (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [626282EA8042]
http://linked.open...i/riv/nazevZdroje
  • BBA - Molecular Basis of Disease
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 1637
http://linked.open...iv/tvurceVysledku
  • Jirsa, Milan
  • Groen, A. K.
  • Kosters, A.
issn
  • 0925-4439
number of pages
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