About: Treatment of patients with achalasia with botulinum toxin - a multicenter prospective cohort study     Goto   Sponge   NotDistinct   Permalink

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Description
  • achalázie; botulin toxin; multicentrická studie (cs)
  • Botulinum toxin (BT) injection is an alternative treatment of achalasia. The aim of the study was to examine outcomes of patients treated with BT in the Czech Republic. Since 1997, 49 patients with achalasia have been treated with BT. We prospectively evaluated the effect of BT injection on 41 patients during a median follow-up of 24 months (range 9-62). Esophageal manometry was performed before and at 3-5 months after the injection. In 16 patients, BT was injected from the antegrade angle only (subgroup A), in 15 patients, BT was injected from both retrograde and antegrade angles (subgroup B) and, in 10 patients, BT injection was combined with subsequent balloon dilatation (subgroup C). Immediate clinical response was achieved in 93% of patients. Clinical remission was sustained beyond 3 months in 83% of patients (responders). Fourteen responders (41%) did not experience a relapse during the median of 22 months. Twenty responders (59%) experienced symptomatic relapse approximately 8 months after the
  • Botulinum toxin (BT) injection is an alternative treatment of achalasia. The aim of the study was to examine outcomes of patients treated with BT in the Czech Republic. Since 1997, 49 patients with achalasia have been treated with BT. We prospectively evaluated the effect of BT injection on 41 patients during a median follow-up of 24 months (range 9-62). Esophageal manometry was performed before and at 3-5 months after the injection. In 16 patients, BT was injected from the antegrade angle only (subgroup A), in 15 patients, BT was injected from both retrograde and antegrade angles (subgroup B) and, in 10 patients, BT injection was combined with subsequent balloon dilatation (subgroup C). Immediate clinical response was achieved in 93% of patients. Clinical remission was sustained beyond 3 months in 83% of patients (responders). Fourteen responders (41%) did not experience a relapse during the median of 22 months. Twenty responders (59%) experienced symptomatic relapse approximately 8 months after the (en)
Title
  • Treatment of patients with achalasia with botulinum toxin - a multicenter prospective cohort study
  • Treatment of patients with achalasia with botulinum toxin - a multicenter prospective cohort study (en)
  • Léčba nemocných s achalázií botulin toxinem - multicentrická prospektivní kohortová studie (cs)
skos:prefLabel
  • Treatment of patients with achalasia with botulinum toxin - a multicenter prospective cohort study
  • Treatment of patients with achalasia with botulinum toxin - a multicenter prospective cohort study (en)
  • Léčba nemocných s achalázií botulin toxinem - multicentrická prospektivní kohortová studie (cs)
skos:notation
  • RIV/00023001:_____/03:00000924!RIV08-MZ0-00023001
http://linked.open.../vavai/riv/strany
  • 204-209
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 631450
http://linked.open...ai/riv/idVysledku
  • RIV/00023001:_____/03:00000924
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • gastroeneterology; toxicology (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [5B272F8093C6]
http://linked.open...i/riv/nazevZdroje
  • Diseases of the esophagus
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 16
http://linked.open...iv/tvurceVysledku
  • Špičák, Julius
  • Martínek, Jan
  • Bureš, J.
  • Široký, M.
  • Hep, A.
  • Plottová, Z.
issn
  • 1120-8694
number of pages
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