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| rdf:type
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| Description
| - Antibacterial activity of stable 1-monoacylglycerol (1-MAG) microemulsions (MEs) of capric (C10:0), undecanoic (C11:0), lauric (C12:0), and myristic (C14:0) acids against the growth of gram-positive and gram-negative bacteria was tested and their inhibition effect was compared to that of neat 1-MAG. To reveal their behavior with respect to eukaryotic cells, the cytotoxicity on mouse fibroblasts was also determined. The MEs were studied via pseudo-ternary phase diagrams in order to find out the miscibility areas of all components used. The results indicated that at 1-MAG concentrations of 1000–1900 mg/L, an inhibition of gram-negative strains was improved compared to neat 1-MAG and depended on the fatty acid type; however, at lower 1-MAG concentrations, both systems showed comparable effect. The opposite trend was detected on gram-positive bacteria, where 1-MAGs showed better performance compared to corresponding MEs. The best antibacterial activity against both bacterial types was observed in 1-MAG C12:0MEs.MTT assay revealed significant cytotoxicity of all MEs. The threshold of 10 mg/L was determined as the limit for moderate toxicity, which represents 40–60% cell survival. All prepared MEs were transparent, stable during the storage period of 6 months and their particle sizes were between 15 and 20 nm.
- Antibacterial activity of stable 1-monoacylglycerol (1-MAG) microemulsions (MEs) of capric (C10:0), undecanoic (C11:0), lauric (C12:0), and myristic (C14:0) acids against the growth of gram-positive and gram-negative bacteria was tested and their inhibition effect was compared to that of neat 1-MAG. To reveal their behavior with respect to eukaryotic cells, the cytotoxicity on mouse fibroblasts was also determined. The MEs were studied via pseudo-ternary phase diagrams in order to find out the miscibility areas of all components used. The results indicated that at 1-MAG concentrations of 1000–1900 mg/L, an inhibition of gram-negative strains was improved compared to neat 1-MAG and depended on the fatty acid type; however, at lower 1-MAG concentrations, both systems showed comparable effect. The opposite trend was detected on gram-positive bacteria, where 1-MAGs showed better performance compared to corresponding MEs. The best antibacterial activity against both bacterial types was observed in 1-MAG C12:0MEs.MTT assay revealed significant cytotoxicity of all MEs. The threshold of 10 mg/L was determined as the limit for moderate toxicity, which represents 40–60% cell survival. All prepared MEs were transparent, stable during the storage period of 6 months and their particle sizes were between 15 and 20 nm. (en)
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| Title
| - Formulation, antibacterial activity, and cytotoxicity of 1-monoacylglycerol microemulsions
- Formulation, antibacterial activity, and cytotoxicity of 1-monoacylglycerol microemulsions (en)
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| skos:prefLabel
| - Formulation, antibacterial activity, and cytotoxicity of 1-monoacylglycerol microemulsions
- Formulation, antibacterial activity, and cytotoxicity of 1-monoacylglycerol microemulsions (en)
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| skos:notation
| - RIV/70883521:28610/14:43871742!RIV15-MSM-28610___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/70883521:28610/14:43871742
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Monoacylglycerol; Microemulsion; Inhibition effect; Cytotoxicity; Bacteria (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - European journal of lipid science and technology
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Buňková, Leona
- Humpolíček, Petr
- Kašpárková, Věra
- Kuceková, Zdenka
- Ševčíková, Petra
- Hauerlandová, Iva
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://bibframe.org/vocab/doi
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| http://localhost/t...ganizacniJednotka
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