About: PAR2 Knock-Out C57Bl6 Mice as a Model for Evaluating Metastases of Cancer Cells: Pilot in Vivo Study of the Metastatic Potential of B16 Melanoma in Knock-Out (PAR2-/-) Animals

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About: PAR2 Knock-Out C57Bl6 Mice as a Model for Evaluating Metastases of Cancer Cells: Pilot in Vivo Study of the Metastatic Potential of B16 Melanoma in Knock-Out (PAR2-/-) Animals Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Metastatic spread was observed in both groups and reached 80 A in PAR2-/- and 50 % in control animals. While in control mice only lung metastases were observed, local tumour recurrence, renal and lung metastases were observed in PAR2-/- mice. The absence of functional PAR-2 could be an important factor influencing the growth and spread of melanoma in vivo, probably associated with tumour cell migration, invasiveness and metastasis formation. Metastatic spread was observed in both groups and reached 80 A in PAR2-/- and 50 % in control animals. While in control mice only lung metastases were observed, local tumour recurrence, renal and lung metastases were observed in PAR2-/- mice. The absence of functional PAR-2 could be an important factor influencing the growth and spread of melanoma in vivo, probably associated with tumour cell migration, invasiveness and metastasis formation. (en)
Title	PAR2 Knock-Out C57Bl6 Mice as a Model for Evaluating Metastases of Cancer Cells: Pilot in Vivo Study of the Metastatic Potential of B16 Melanoma in Knock-Out (PAR2-/-) Animals PAR2 Knock-Out C57Bl6 Mice as a Model for Evaluating Metastases of Cancer Cells: Pilot in Vivo Study of the Metastatic Potential of B16 Melanoma in Knock-Out (PAR2-/-) Animals (en)
skos:prefLabel	PAR2 Knock-Out C57Bl6 Mice as a Model for Evaluating Metastases of Cancer Cells: Pilot in Vivo Study of the Metastatic Potential of B16 Melanoma in Knock-Out (PAR2-/-) Animals PAR2 Knock-Out C57Bl6 Mice as a Model for Evaluating Metastases of Cancer Cells: Pilot in Vivo Study of the Metastatic Potential of B16 Melanoma in Knock-Out (PAR2-/-) Animals (en)
skos:notation	RIV/68407700:21340/12:00199955!RIV13-MSM-21340___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GP309/09/P204), P(NS10423), S
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kukal, Jaromír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	České vysoké učení technické v Praze / Fakulta jaderná a fyzikálně inženýrská
http://linked.open...dnocenehoVysledku	157904
http://linked.open...ai/riv/idVysledku	RIV/68407700:21340/12:00199955
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	PAR-2; trypsin; melanoma; metastasis; knock-out (en)
http://linked.open.../riv/klicoveSlovo	PAR-2 metastasis melanoma trypsin knock-out
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[7EA31115B899]
http://linked.open...i/riv/nazevZdroje	Folia Biologica
http://linked.open...in/vavai/riv/obor	JD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of PAR-2 in neurodegenerative diseases PAR´s, chemokines and their receptors´ expression changes in pulmonary fibrosing processes and in pulmonary processes with alveolar number reduction without scaring (IPF vs. COPD)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	58
http://linked.open...iv/tvurceVysledku	Kukal, Jaromír Matej, R. Olejar, T. Poucková, P. Zadinova, M.
http://linked.open...ain/vavai/riv/wos	000303140600006
issn	0015-5500
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	21340

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