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| rdf:type
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| rdfs:seeAlso
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| Description
| - Platinum(II) dichlorido and oxalato (ox) complexes of the composition cis-[PtCl2(Haza)(2)] (I) and [Pt(ox) (Haza)(2)].H2O(II.H2O) were prepared by a one-step syntheses from K-2[PtCl4] and K-2[Pt(ox)(2)].2H2O, respectively (Haza symbolises 7-azaindole). The complexes were characterised by a set of spectroscopic methods (IR, Raman and multinuclear and 2D NMR), as well as by mass spectrometry, elemental (C, H, and N) and thermal (TG/DTA) analyses. Single-crystal X-ray analysis was performed for cis-[PtCl2(Haza)(2)].DMF (I.DMF) and [Pt(ox)(Haza)(2)] (II), obtained by recrystallization of the complexes I and II center dot H2O from N,N'-dimethylformamide (DMF). Both complexes, of a square-planar geometry, involve a tetracoordinated central Pt(II) atom with two monodentate N7-coordinated 7-azaindole molecules in cis-positions, and with the coordination sphere completed by two chloride anions (I; PtN2Cl2 donor set) or one bidentate-coordinated oxalate dianion (II: PtN2O2 donor set). The complexes did not show any in vitro cytotoxic effect, as evaluated by an MTT assay against breast adenocarcinoma and osteosarcoma human cancer cell lines up to a concentration of 1.0 uM (for I) and 0.1 uM (for II.H2O), given by their limited solubility in the medium used.
- Platinum(II) dichlorido and oxalato (ox) complexes of the composition cis-[PtCl2(Haza)(2)] (I) and [Pt(ox) (Haza)(2)].H2O(II.H2O) were prepared by a one-step syntheses from K-2[PtCl4] and K-2[Pt(ox)(2)].2H2O, respectively (Haza symbolises 7-azaindole). The complexes were characterised by a set of spectroscopic methods (IR, Raman and multinuclear and 2D NMR), as well as by mass spectrometry, elemental (C, H, and N) and thermal (TG/DTA) analyses. Single-crystal X-ray analysis was performed for cis-[PtCl2(Haza)(2)].DMF (I.DMF) and [Pt(ox)(Haza)(2)] (II), obtained by recrystallization of the complexes I and II center dot H2O from N,N'-dimethylformamide (DMF). Both complexes, of a square-planar geometry, involve a tetracoordinated central Pt(II) atom with two monodentate N7-coordinated 7-azaindole molecules in cis-positions, and with the coordination sphere completed by two chloride anions (I; PtN2Cl2 donor set) or one bidentate-coordinated oxalate dianion (II: PtN2O2 donor set). The complexes did not show any in vitro cytotoxic effect, as evaluated by an MTT assay against breast adenocarcinoma and osteosarcoma human cancer cell lines up to a concentration of 1.0 uM (for I) and 0.1 uM (for II.H2O), given by their limited solubility in the medium used. (en)
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| Title
| - Cisplatin and oxaliplatin derivatives involving 7-azaindole: Structural characterisations
- Cisplatin and oxaliplatin derivatives involving 7-azaindole: Structural characterisations (en)
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| skos:prefLabel
| - Cisplatin and oxaliplatin derivatives involving 7-azaindole: Structural characterisations
- Cisplatin and oxaliplatin derivatives involving 7-azaindole: Structural characterisations (en)
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| skos:notation
| - RIV/61989592:15310/12:33140839!RIV13-MSM-15310___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(ED2.1.00/03.0058), P(EE2.3.20.0017), P(GAP207/11/0841), S
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15310/12:33140839
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - In vitro cytotoxicity; Multinuclear NMR; X-ray structure; 7-Azaindole; Platinum(II) complexes (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Marek, Jaromír
- Trávníček, Zdeněk
- Štarha, Pavel
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| http://linked.open...ain/vavai/riv/wos
| |
| issn
| |
| number of pages
| |
| http://bibframe.org/vocab/doi
| - 10.1016/j.poly.2011.11.059
|
| http://localhost/t...ganizacniJednotka
| |
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