About: RNASTAR: An RNA STructural Alignment Repository that provides insight into the evolution of natural and artificial RNAs

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About: RNASTAR: An RNA STructural Alignment Repository that provides insight into the evolution of natural and artificial RNAs Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Automated RNA alignment algorithms often fail to recapture the essential conserved sites that are critical for function. To assist in the refinement of these algorithms, we manually curated a set of 148 alignments with a total of 9600 unique sequences, in which each alignment was backed by at least one crystal or NMR structure. These alignments included both naturally and artificially selected molecules. We used principles of isostericity to improve the alignments from an average of 83%-94% isosteric base pairs. We expect that this alignment collection will assist in a wide range of benchmarking efforts and provide new insight into evolutionary principles governing change in RNA structural motifs. The improved alignments have been contributed to the Rfam database. Automated RNA alignment algorithms often fail to recapture the essential conserved sites that are critical for function. To assist in the refinement of these algorithms, we manually curated a set of 148 alignments with a total of 9600 unique sequences, in which each alignment was backed by at least one crystal or NMR structure. These alignments included both naturally and artificially selected molecules. We used principles of isostericity to improve the alignments from an average of 83%-94% isosteric base pairs. We expect that this alignment collection will assist in a wide range of benchmarking efforts and provide new insight into evolutionary principles governing change in RNA structural motifs. The improved alignments have been contributed to the Rfam database. (en)
Title	RNASTAR: An RNA STructural Alignment Repository that provides insight into the evolution of natural and artificial RNAs RNASTAR: An RNA STructural Alignment Repository that provides insight into the evolution of natural and artificial RNAs (en)
skos:prefLabel	RNASTAR: An RNA STructural Alignment Repository that provides insight into the evolution of natural and artificial RNAs RNASTAR: An RNA STructural Alignment Repository that provides insight into the evolution of natural and artificial RNAs (en)
skos:notation	RIV/61388963:_____/12:00377926!RIV13-AV0-61388963
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ME09019), Z(AV0Z40550506)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Chocholoušová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	165809
http://linked.open...ai/riv/idVysledku	RIV/61388963:_____/12:00377926
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	RNA; RNASTAR; alignment; repository (en)
http://linked.open.../riv/klicoveSlovo	RNA alignment RNASTAR repository
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[F87C58F75A3E]
http://linked.open...i/riv/nazevZdroje	R N A
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	Theoretical investigation of RNA structure, dynamics and function and their relationship.
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	18
http://linked.open...iv/tvurceVysledku	Quinn, J. Chocholoušová, Jana Gardner, P. Iyer, M. Knight, R. Liu, Z. Lozupone, C. A. McDonald, D. Smit, S. Stombaugh, J. Widmann, J. Wikman, S. Zaneveld, J. R. R.
http://linked.open...ain/vavai/riv/wos	000305349000002
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství
issn	1355-8382
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1261/rna.032052.111

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