Attributes | Values |
---|
rdf:type
| |
Description
| - Extracellular part of human glutamate carboxypeptidase II was co-crystallized with the phosphapeptide analogs of the enzyme substrates folyl-gamma-glutamate, aspartyl-glutamate, and gamma-glutamyl-glutamate. The determination of the crystal structures allowed us to describe the S1 site of the enzyme in detail for the first time and the corresponding enzyme-ligand interactions, too. Biochemical experiments provided additional information about the influence of the nature of the fragment in the P1 position of the substrate on the hydrolysis rate.
- Extracellular part of human glutamate carboxypeptidase II was co-crystallized with the phosphapeptide analogs of the enzyme substrates folyl-gamma-glutamate, aspartyl-glutamate, and gamma-glutamyl-glutamate. The determination of the crystal structures allowed us to describe the S1 site of the enzyme in detail for the first time and the corresponding enzyme-ligand interactions, too. Biochemical experiments provided additional information about the influence of the nature of the fragment in the P1 position of the substrate on the hydrolysis rate. (en)
- Extracelulární část lidské glutamátkarboxypeptidasy II byla vykrystalizována v komplexu s fosfapeptidovými analogy jejích substrátů folyl-gamma-glutamátu, aspartyl-glutamátu a gamma-glutamyl-glutamátu. Rentgenostrukturní analýza umožnila poprvé detailně popsat S1 podmísto enzymu a příslušné interakce s ligandem. Další informace o vlivu druhu fragmentu v P1 pozici substrátu na hydrolýzu poskytla doplňující biochemická měření. (cs)
|
Title
| - Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs
- Strukturální podstata interakcí lidské glutamát karboxypeptidasy II a analogů jejích substrátů (cs)
- Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs (en)
|
skos:prefLabel
| - Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs
- Strukturální podstata interakcí lidské glutamát karboxypeptidasy II a analogů jejích substrátů (cs)
- Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs (en)
|
skos:notation
| - RIV/61388963:_____/08:00306830!RIV08-AV0-61388963
|
http://linked.open.../vavai/riv/strany
| |
http://linked.open...avai/riv/aktivita
| |
http://linked.open...avai/riv/aktivity
| - P(1M0508), Z(AV0Z40550506), Z(MSM 113100001)
|
http://linked.open...iv/cisloPeriodika
| |
http://linked.open...vai/riv/dodaniDat
| |
http://linked.open...aciTvurceVysledku
| |
http://linked.open.../riv/druhVysledku
| |
http://linked.open...iv/duvernostUdaju
| |
http://linked.open...titaPredkladatele
| |
http://linked.open...dnocenehoVysledku
| |
http://linked.open...ai/riv/idVysledku
| - RIV/61388963:_____/08:00306830
|
http://linked.open...riv/jazykVysledku
| |
http://linked.open.../riv/klicovaSlova
| - prostate-specific membrane antigen; metallopeptidase; folate hydrolase; NAALADase; phosphapeptide (en)
|
http://linked.open.../riv/klicoveSlovo
| |
http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
|
http://linked.open...ontrolniKodProRIV
| |
http://linked.open...i/riv/nazevZdroje
| - Journal of Molecular Biology
|
http://linked.open...in/vavai/riv/obor
| |
http://linked.open...ichTvurcuVysledku
| |
http://linked.open...cetTvurcuVysledku
| |
http://linked.open...vavai/riv/projekt
| |
http://linked.open...UplatneniVysledku
| |
http://linked.open...v/svazekPeriodika
| |
http://linked.open...iv/tvurceVysledku
| - Konvalinka, Jan
- Lubkowski, J.
- Hlouchová, Klára
- Rovenská, Miroslava
- Slusher, B. S.
- Tsukamoto, T.
- Bařinka, C.
- Dauter, M.
- Hin, N.
- Ko, Y. S.
- Majer, P.
|
http://linked.open...n/vavai/riv/zamer
| |
issn
| |
number of pages
| |