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rdf:type
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Description
| - Aspartátové proteasy sekretované C. albicans (Sap2p), C. tropicalis (Sapt1p) a C. parapsilosis (Sapp1p) byly purifikovány a testovány se sérií různě modifikovaných peptidomimetických inhibitorů. Vybrané látky inhibovaly proteasy v nanomolárních koncentracích. Srovnání primárních struktur a homologní modelování struktury (Sapp1p) se známými strukturami Sapt1p a komplexu inhibitoru se Sap2p umožnily identifikovat strukturní prvky odpovědné za rozdílnou inhibici jednotlivých proteas. (cs)
- Aspartic proteases secreted by C. albicans (Sap2p), C. tropicalis (Sapt1p), and C. parapsilosis (Sapp1p) were purified and tested for inhibition with a series of peptidomimetic inhibitors with different modifications. Selected compounds inhibited proteases in nanomolar concentration. The sequence alignment of Sap2p, Sapt1p, and Sapp1p and homology modeling of Sapp1p with the crystal structure of Sapt1p and the complex of Sap2p with a peptidomimetic inhibitor identified structural differences, which lead to different susceptibility of individual proteases to inhibition.
- Aspartic proteases secreted by C. albicans (Sap2p), C. tropicalis (Sapt1p), and C. parapsilosis (Sapp1p) were purified and tested for inhibition with a series of peptidomimetic inhibitors with different modifications. Selected compounds inhibited proteases in nanomolar concentration. The sequence alignment of Sap2p, Sapt1p, and Sapp1p and homology modeling of Sapp1p with the crystal structure of Sapt1p and the complex of Sap2p with a peptidomimetic inhibitor identified structural differences, which lead to different susceptibility of individual proteases to inhibition. (en)
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Title
| - Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling
- Srovnání specifit a struktur sekretovaných aspartátových proteas z Candidy parapsilosis, Candidy albicans a Candidy tropicalis pomocí peptidomimetických inhibitorů a homologního modelování (cs)
- Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling (en)
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skos:prefLabel
| - Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling
- Srovnání specifit a struktur sekretovaných aspartátových proteas z Candidy parapsilosis, Candidy albicans a Candidy tropicalis pomocí peptidomimetických inhibitorů a homologního modelování (cs)
- Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling (en)
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skos:notation
| - RIV/61388963:_____/06:00043419!RIV07-AV0-61388963
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA303/04/0432), P(LC531), Z(AV0Z40550506)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61388963:_____/06:00043419
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Candida albicans; Candida parapsilosis; Candida inhibitors; secreted aspartic protease (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Pichová, Iva
- Hrušková, Olga
- Pavlíčková, Libuše
- Majer, F.
- Majer, P.
- Hradilek, Martin
- Dolejší, Elena
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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