About: Mechanical response of porous scaffolds for cartilage engineering

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this paper, the effect of modification of the cross-linked collagen I with hyaluronic acid, hydroxyapatite nanoparticles and chitosan nanofibers on the mechanical response of the compact scaffold material and the lyophilized porous scaffold construct has been investigated in the dry state at 37 oC under tensile loading. The results showed that the addition of hyaluronic acid reduced the tensile elastic modulus and slightly increased the ultimate deformation of crosslinked collagen I under the test conditions used. On the other hand, addition of hydroxyapatite nanoparticles and chitosan nanofibers, respectively, increased the elastic modulus of the modified collagen ten-fold and four-fold, respectively. The ultimate tensile deformation has been decreased by hydroxyapatite and increased by the chitosan nanofibers. In this paper, the effect of modification of the cross-linked collagen I with hyaluronic acid, hydroxyapatite nanoparticles and chitosan nanofibers on the mechanical response of the compact scaffold material and the lyophilized porous scaffold construct has been investigated in the dry state at 37 oC under tensile loading. The results showed that the addition of hyaluronic acid reduced the tensile elastic modulus and slightly increased the ultimate deformation of crosslinked collagen I under the test conditions used. On the other hand, addition of hydroxyapatite nanoparticles and chitosan nanofibers, respectively, increased the elastic modulus of the modified collagen ten-fold and four-fold, respectively. The ultimate tensile deformation has been decreased by hydroxyapatite and increased by the chitosan nanofibers. (en)
Title	Mechanical response of porous scaffolds for cartilage engineering Mechanical response of porous scaffolds for cartilage engineering (en)
skos:prefLabel	Mechanical response of porous scaffolds for cartilage engineering Mechanical response of porous scaffolds for cartilage engineering (en)
skos:notation	RIV/00216224:14110/07:00024236!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1ET400110403), P(2B06130), P(IAA500390702), Z(AV0Z50390512), Z(MSM0021630501)
http://linked.open...iv/cisloPeriodika	Suppl. 1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Jančář, Josef Gál, Petr Amler, Evžen Krupa, Petr Plánka, Ladislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	432585
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/07:00024236
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Chitosan; Nanofibers; Hyaluronic acid; Hydroxyapatite; Mesenchymal stem cells; Joint resurfacing (en)
http://linked.open.../riv/klicoveSlovo	Joint resurfacing Hyaluronic acid Mesenchymal stem cells Chitosan Hydroxyapatite Nanofibers
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[BC52490CD790]
http://linked.open...i/riv/nazevZdroje	Physiological Research
http://linked.open...in/vavai/riv/obor	FI
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Protein computer modeling and molecular dynamics simulation Synthesis of new biomaterials and preparation of stem cell derived cells, and their aplications in for the treatment of diseases affecting human tissues derived from mesoderm: cartilage, bone, ligament and meniscus. Scaffolds from liposome nanofibers for tissue engineering
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	56
http://linked.open...iv/tvurceVysledku	Jančář, Josef Nečas, Alois Amler, Evžen Krupa, Petr Gál, Petr Plánka, Ladislav Kecová, Helga Slovikova, Alexandra
http://linked.open...ain/vavai/riv/wos	000252436800003
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie Multifunkční heterogenní materiály na bázi syntetických polymerů a biopolymerů
issn	0862-8408
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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