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Description
| - A series of heterocyclic derivatives analogous to (-)vasicinone, in which the vasicinone C-ring was replaced with alkyl chain terminated by tertiary amine was prepared. N3, C4-O, C4-S or C4-N were used as the sites of attachment. The 4-[3-(1-piperidyl)propylsulfanyl]derivatives displayed bronchodilatory effect at low micromolar concentrations on isolated rat trachea, and low toxicity both on Balb/c 3T3 mouse fibroblast cells and in mice.
- A series of heterocyclic derivatives analogous to (-)vasicinone, in which the vasicinone C-ring was replaced with alkyl chain terminated by tertiary amine was prepared. N3, C4-O, C4-S or C4-N were used as the sites of attachment. The 4-[3-(1-piperidyl)propylsulfanyl]derivatives displayed bronchodilatory effect at low micromolar concentrations on isolated rat trachea, and low toxicity both on Balb/c 3T3 mouse fibroblast cells and in mice. (en)
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Title
| - Novel bronchodilatory quinazolines and quinoxalines: Synthesis and biological evaluation
- Novel bronchodilatory quinazolines and quinoxalines: Synthesis and biological evaluation (en)
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skos:prefLabel
| - Novel bronchodilatory quinazolines and quinoxalines: Synthesis and biological evaluation
- Novel bronchodilatory quinazolines and quinoxalines: Synthesis and biological evaluation (en)
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skos:notation
| - RIV/00216208:11160/14:10282274!RIV15-MSM-11160___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(EE2.3.30.0061), P(GAP207/10/2048), S
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11160/14:10282274
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Toxicity; Bronchodilator; Synthesis; Quinazoline; Vasicinone (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - FR - Francouzská republika
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - European Journal of Medicinal Chemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Kuneš, Jiří
- Vacek, Jan
- Pour, Milan
- Gathergood, Nicholas
- Špulák, Marcel
- Mikušek, Jiří
- Ghavre, Mukund
- Pourová, Jana
- Vopršalová, Marie
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.ejmech.2013.12.024
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http://localhost/t...ganizacniJednotka
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