About: Soman poisoning alters p38 MAPK pathway in rat cerebellar Purkinje cells

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About: Soman poisoning alters p38 MAPK pathway in rat cerebellar Purkinje cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of the study was to evaluate the expression of phosphorylated p38 mitogen-activated protein kinase (p38 MAPK) and MAPK-activated transcription factors elk-1, c-jun and c-myc in rat cerebellar Purkinje cells after soman poisoning to investigate the pathogenetic mechanism of non-specific long-term adverse effects of nerve agents. The results suggest that late activation of p38 MAPK and their targets might be the underlying mechanism of chronic neurophysiological adverse effects of soman. The aim of the study was to evaluate the expression of phosphorylated p38 mitogen-activated protein kinase (p38 MAPK) and MAPK-activated transcription factors elk-1, c-jun and c-myc in rat cerebellar Purkinje cells after soman poisoning to investigate the pathogenetic mechanism of non-specific long-term adverse effects of nerve agents. The results suggest that late activation of p38 MAPK and their targets might be the underlying mechanism of chronic neurophysiological adverse effects of soman. (en)
Title	Soman poisoning alters p38 MAPK pathway in rat cerebellar Purkinje cells Soman poisoning alters p38 MAPK pathway in rat cerebellar Purkinje cells (en)
skos:prefLabel	Soman poisoning alters p38 MAPK pathway in rat cerebellar Purkinje cells Soman poisoning alters p38 MAPK pathway in rat cerebellar Purkinje cells (en)
skos:notation	RIV/00216208:11150/09:00208527!RIV10-MO0-11150___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Mičuda, Stanislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	342326
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/09:00208527
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	soman; p38; c-Myc; c-Jun; Elk-1; cerebellum; Purkinje cells (en)
http://linked.open.../riv/klicoveSlovo	soman p38 Purkinje cells cerebellum c-Myc Elk-1 c-Jun
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[296DBA3C6309]
http://linked.open...i/riv/nazevZdroje	Journal of Applied Toxicology
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Kassa, Jiří Mičuda, Stanislav Pejchal, Jaroslav Tichý, Aleš Zárybnická, Lenka Šinkorová, Zuzana Osterreicher, Jan
http://linked.open...ain/vavai/riv/wos	000266507600009
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	0260-437X
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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