About: Liquid chromatography-tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes

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About: Liquid chromatography-tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Amlodipine is a chiral calcium channel blocker. Racemic mixture is used in clinical practice even though it is known that only S-amlodipine possess vasodilating properties. Chiral aspects of biotransformation were studied by incubation of amlodipine and its two individual enantiomers with rat hepatocytes. Eight metabolites presented in the highest amount were identified and semiquantified. Amlodipine is a chiral calcium channel blocker. Racemic mixture is used in clinical practice even though it is known that only S-amlodipine possess vasodilating properties. Chiral aspects of biotransformation were studied by incubation of amlodipine and its two individual enantiomers with rat hepatocytes. Eight metabolites presented in the highest amount were identified and semiquantified. (en) Amlodipin je chirální blokátor kalciových kanálů. V klinické praxi se užívá racemát, ačkoliv je známo, že vazodilatační vlastnosti vykazuje pouze S-amlodipin. Při studiu chirálních aspektů biotransformace byl s hepatocyty potkana inkubován jak racemát amlodipinu, tak oba jeho enantiomery. Identifikováno a semikvantitativně stanovováno bylo 8 metabolitů přítomných v nejvyšších koncentracích. (cs)
Title	Liquid chromatography-tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes Kapalinová chromatografie standemovou hmotnostní spektrometrií (LC-MS/MS) vchirální studii biotransformace amlodipinu hepatocyty potkana (cs) Liquid chromatography-tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes (en)
skos:prefLabel	Liquid chromatography-tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes Kapalinová chromatografie standemovou hmotnostní spektrometrií (LC-MS/MS) vchirální studii biotransformace amlodipinu hepatocyty potkana (cs) Liquid chromatography-tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes (en)
skos:notation	RIV/00216208:11150/06:00004339!RIV07-MSM-11150___
http://linked.open.../vavai/riv/strany	273;283
http://linked.open...avai/riv/aktivita	V Z
http://linked.open...avai/riv/aktivity	V, Z(MSM0021620820)
http://linked.open...iv/cisloPeriodika	573-574
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Šišpera, Luděk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	483414
http://linked.open...ai/riv/idVysledku	RIV/00216208:11150/06:00004339
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	liquid chromatography; LC-MS/MS; amlodipine; stereoselective metabolism; in vitro (en)
http://linked.open.../riv/klicoveSlovo	stereoselective metabolism LC-MS/MS amlodipine liquid chromatography in vitro
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[058EF4454EBA]
http://linked.open...i/riv/nazevZdroje	Analytica Chimica Acta
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	2006
http://linked.open...iv/tvurceVysledku	Šišpera, Luděk
http://linked.open...n/vavai/riv/zamer	The use of experimental and clinical models of metabolic processes, nutrition and pharmacotherapy for the advancement of knowledge, clinical practice and quality of life improvement
issn	0003-2670
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	11150

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