| Attributes | Values |
|---|
| rdf:type
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| Description
| - Context: Soluble CD163 was suggested as a biomarker of insulin sensitivity and CD163 mRNA expression representing macrophage content in adipose tissue (AT). Objective: The aim of this study was to investigate, in cross-sectional and prospective design, the relationship between sCD163 circulating levels and, CD163 mRNA expression in adipose tissue and insulin sensitivity assessed by euglycemic-hyperinsulinemic clamp. Design, Setting, Participants, and Interventions: Two cohorts of subjects were examined in the study. Cohort 1: forty-two women with wide range of BMI (17-48 kg/m2); Cohort 2: twenty-seven obese women, who followed a dietary intervention consisting of 1 month very low-calorie diet, and 5 months of weight-stabilization period. Main Outcome Measures: Serum levels of CD163 and mRNA expression of CD163 and CD68 in subcutaneous and visceral AT were determined, and insulin sensitivity (expressed as glucose disposal rate (GDR)) was measured in Cohort I. In Cohort 2, serum levels of CD163, mRNA expressions of CD163, CD68, and CD163-shedding factors (TACE and TIPM3) in subcutaneous AT were examined and GDR was measured before and during dietary intervention. Results: In Cohort 1, circulating sCD163 correlated with CD163 mRNA levels in both subcutaneous and visceral AT. sCD163 and CD163 mRNA expression in both fat depots correlated with GDR. In Cohort 2, the diet-induced changes of sCD163 levels did not correlate with those of CD163, CD 68, TACE and TIMP3 mRNA levels. Although the pattern of the diet-induced change of sCD163 paralleled that of GDR there was no correlation between the changes of these two variables. Conclusion: sCD163 correlates with CD163 mRNA expression in subcutaneous and visceral AT and with whole-body insulin sensitivity in steady state condition. These associations are not observed in respect to the diet-induced changes during weight-reducing hypocaloric diet.
- Context: Soluble CD163 was suggested as a biomarker of insulin sensitivity and CD163 mRNA expression representing macrophage content in adipose tissue (AT). Objective: The aim of this study was to investigate, in cross-sectional and prospective design, the relationship between sCD163 circulating levels and, CD163 mRNA expression in adipose tissue and insulin sensitivity assessed by euglycemic-hyperinsulinemic clamp. Design, Setting, Participants, and Interventions: Two cohorts of subjects were examined in the study. Cohort 1: forty-two women with wide range of BMI (17-48 kg/m2); Cohort 2: twenty-seven obese women, who followed a dietary intervention consisting of 1 month very low-calorie diet, and 5 months of weight-stabilization period. Main Outcome Measures: Serum levels of CD163 and mRNA expression of CD163 and CD68 in subcutaneous and visceral AT were determined, and insulin sensitivity (expressed as glucose disposal rate (GDR)) was measured in Cohort I. In Cohort 2, serum levels of CD163, mRNA expressions of CD163, CD68, and CD163-shedding factors (TACE and TIPM3) in subcutaneous AT were examined and GDR was measured before and during dietary intervention. Results: In Cohort 1, circulating sCD163 correlated with CD163 mRNA levels in both subcutaneous and visceral AT. sCD163 and CD163 mRNA expression in both fat depots correlated with GDR. In Cohort 2, the diet-induced changes of sCD163 levels did not correlate with those of CD163, CD 68, TACE and TIMP3 mRNA levels. Although the pattern of the diet-induced change of sCD163 paralleled that of GDR there was no correlation between the changes of these two variables. Conclusion: sCD163 correlates with CD163 mRNA expression in subcutaneous and visceral AT and with whole-body insulin sensitivity in steady state condition. These associations are not observed in respect to the diet-induced changes during weight-reducing hypocaloric diet. (en)
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| Title
| - Soluble CD163 is associated with CD163 mRNA expression in adipose tissue and with insulin sensitivity in steady state condition but not in response to calorie restriction
- Soluble CD163 is associated with CD163 mRNA expression in adipose tissue and with insulin sensitivity in steady state condition but not in response to calorie restriction (en)
|
| skos:prefLabel
| - Soluble CD163 is associated with CD163 mRNA expression in adipose tissue and with insulin sensitivity in steady state condition but not in response to calorie restriction
- Soluble CD163 is associated with CD163 mRNA expression in adipose tissue and with insulin sensitivity in steady state condition but not in response to calorie restriction (en)
|
| skos:notation
| - RIV/00216208:11120/14:43908016!RIV15-MSM-11120___
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| |
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11120/14:43908016
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - adipose tissue; insulin sensitivity (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Journal of Clinical Endocrinology and Metabolism
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Kováčová, Zuzana
- Polák, Jan
- Štich, Vladimír
- Klimčáková, Eva
- Rossmeislová, Lenka
- Kračmerová, Jana
- Tencerová, Michaela
- Mališová, Lucia
- Langin, Dominique
- Šiklová, Michaela
|
| http://linked.open...ain/vavai/riv/wos
| |
| issn
| |
| number of pages
| |
| http://bibframe.org/vocab/doi
| |
| http://localhost/t...ganizacniJednotka
| |
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