About: Synthesis of unsymmetric cyanine dye via merocyanine and their interaction with DNA

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	An effective method has been developed for synthesis of neutral merocyanine dye 4 from (4-nitrophenyl) malondialdehyde. Merocyanine 4 was used as a basic building block for preparation of unsymmetric cyanine dyes 9 and 10, both derived from the same aromatic malondialdehyde. With the cyanine 10, pH-dependent affinity to DNA has been studied. Unsymmetric cyanine dye 10 has been compared with symmetric dye 8. The corresponding binding constants (K) have been calculated for various pH. An effective method has been developed for synthesis of neutral merocyanine dye 4 from (4-nitrophenyl) malondialdehyde. Merocyanine 4 was used as a basic building block for preparation of unsymmetric cyanine dyes 9 and 10, both derived from the same aromatic malondialdehyde. With the cyanine 10, pH-dependent affinity to DNA has been studied. Unsymmetric cyanine dye 10 has been compared with symmetric dye 8. The corresponding binding constants (K) have been calculated for various pH. (en)
Title	Synthesis of unsymmetric cyanine dye via merocyanine and their interaction with DNA Synthesis of unsymmetric cyanine dye via merocyanine and their interaction with DNA (en)
skos:prefLabel	Synthesis of unsymmetric cyanine dye via merocyanine and their interaction with DNA Synthesis of unsymmetric cyanine dye via merocyanine and their interaction with DNA (en)
skos:notation	RIV/68378050:_____/09:00347152!RIV11-AV0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/09/1311), P(KAN200200651), P(LC512), Z(AV0Z50520514), Z(MSM0021620806)
http://linked.open...iv/cisloPeriodika	7-8
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Králová, Jarmila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	345124
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/09:00347152
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	malondialdehyde; merocyanine; DNA (en)
http://linked.open.../riv/klicoveSlovo	DNA malondialdehyde merocyanine
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[BD08CAAF6CA5]
http://linked.open...i/riv/nazevZdroje	Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Synthetic probes for recognition of tumor markers:applications for cell directed apoptosis and targeted photodynamic therapy Nanoparticulate and supramolecular systems for targeted drug delivery Center for biomolecules and complex molecular systems
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	78
http://linked.open...iv/tvurceVysledku	Bříza, T. Kejík, Z. Král, V. Králová, Jarmila Martásek, P.
http://linked.open...ain/vavai/riv/wos	000269891900005
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů
issn	0010-0765
number of pages	10 (xsd:int)

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