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  • It is hypothesized that development of platinum compounds structurally dissimilar to cisplatin may lead to agents with a spectrum of clinical activity complementary to the parent drug. Moreover, as DNA is considered the major pharmacological target of platinum compounds, the latter hypothesis also implies that platinum agents which bind to DNA in a fundamentally different manner to that of cisplatin may have altered pharmacological properties.
  • It is hypothesized that development of platinum compounds structurally dissimilar to cisplatin may lead to agents with a spectrum of clinical activity complementary to the parent drug. Moreover, as DNA is considered the major pharmacological target of platinum compounds, the latter hypothesis also implies that platinum agents which bind to DNA in a fundamentally different manner to that of cisplatin may have altered pharmacological properties. (en)
  • Byla navržena hypotéza, že vývoj platinových sloučenin strukturně odlišných od cisplatiny může vést k syntéze látek, jejichž spektrum klinické aktivity je komplementární k původní cisplatině. Vzhledem k tomu, že DNA je považována za hlavní cílové místo farmakologického působení platinových sloučenin, z této hypotézy vyplývá, že platinové sloučeniny, které se váží k DNA způsobem zásadně odlišným od cisplatiny mohou vykazovat odlišné farmakologické vlastnosti. (cs)
Title
  • Mechanism of the anti-tumor activity of platinum complexes
  • Mechanismus protinádorové aktivity komplexů platiny (cs)
  • Mechanism of the anti-tumor activity of platinum complexes (en)
skos:prefLabel
  • Mechanism of the anti-tumor activity of platinum complexes
  • Mechanismus protinádorové aktivity komplexů platiny (cs)
  • Mechanism of the anti-tumor activity of platinum complexes (en)
skos:notation
  • RIV/68081707:_____/05:00022934!RIV06-AV0-68081707
http://linked.open.../vavai/riv/strany
  • 73;90
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50040507)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
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  • 529350
http://linked.open...ai/riv/idVysledku
  • RIV/68081707:_____/05:00022934
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http://linked.open.../riv/klicovaSlova
  • DNA; cancer; platinum drugs (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [1D9C23E27027]
http://linked.open...i/riv/mistoVydani
  • České Budějovice
http://linked.open...i/riv/nazevZdroje
  • Advances in Cell and Molecular Biology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Brabec, Viktor
http://linked.open...n/vavai/riv/zamer
number of pages
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  • Kopp Publishing
https://schema.org/isbn
  • 80-7232-263-X
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