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Description
  • Změny v chemické struktuře platinových sloučenin mohou podstatným způsobem změnit jejich vazbu k DNA, následné rozlišení takto vzniklého poškození DNA buněčnými proteiny a tedy i mechanismus biologického působení těchto sloučenin. Takové strukturní modifikace mohou také ovlivnit spektrum protinádorové aktivity platinových cytostatik a vznik rezistence vůči těmto látkám, stejně tak jako profil jejich toxického působení. Podrobné znalosti způsobu, jak modifikace DNA protinádorově působícími komplexy platiny a jiných kovů ovlivňují biologické procesy, by mohla poskytnout základ pro porozumění mechanismu cytostatického působení platinových léčiv a tedy i racionální poznatkovou základnu pro navržení nových léčiv na bázi těžkých kovů a pro určení optimální strategie léčby. (cs)
  • Changing the chemical structure of platinum compounds may substantially modulate their DNA binding mode, subsequent processing of DNA damage and consequently the mechanism of biological efficacy of these compounds. These structural modifications may also affect the spectrum of biological activity of the platinum agents and the development of drug resistance, and also their toxicity profile. Complete knowledge of how modifications of DNA by anti-tumor platinum compounds and other metal-based drugs affect the components of these pathways should provide a basis for understanding the mechanism of action of platinum drugs and, thereby, a rational basis for the design of new metal-based drugs and to identify optimal treatment strategies.
  • Changing the chemical structure of platinum compounds may substantially modulate their DNA binding mode, subsequent processing of DNA damage and consequently the mechanism of biological efficacy of these compounds. These structural modifications may also affect the spectrum of biological activity of the platinum agents and the development of drug resistance, and also their toxicity profile. Complete knowledge of how modifications of DNA by anti-tumor platinum compounds and other metal-based drugs affect the components of these pathways should provide a basis for understanding the mechanism of action of platinum drugs and, thereby, a rational basis for the design of new metal-based drugs and to identify optimal treatment strategies. (en)
Title
  • Platinum-based drugs
  • Farmaka odvozená od platiny (cs)
  • Platinum-based drugs (en)
skos:prefLabel
  • Platinum-based drugs
  • Farmaka odvozená od platiny (cs)
  • Platinum-based drugs (en)
skos:notation
  • RIV/68081707:_____/05:00001335!RIV06-AV0-68081707
http://linked.open.../vavai/riv/strany
  • 489;506
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(IAA5004101), P(IBS5004009), P(KJB5004301), Z(AV0Z50040507)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 536202
http://linked.open...ai/riv/idVysledku
  • RIV/68081707:_____/05:00001335
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • DNA; platinum; cancer (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [AEF9E87BF91E]
http://linked.open...i/riv/mistoVydani
  • Chichester
http://linked.open...i/riv/nazevZdroje
  • Metallotherapeutic drugs and metal-based diagnostic agents: the use of metals in medicine
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Brabec, Viktor
  • Kašpárková, Jana
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • John Wiley & Sons, Ltd
https://schema.org/isbn
  • 0-470-86403-6
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