About: Effects of monofunctional adducts of Platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes

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About: Effects of monofunctional adducts of Platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Byl popsán vliv vzniku monofunkčních aduktů platnatých komplexů na termodynamickou stabilitu DNA a důsledky vyvolaných změn v termodynamické stabilitě modifikované DNA na její opravu složkami excisní nukleotidové opravy. (cs) Effects of adducts of [PtCl(NH3)(3)] Cl or chlorodiethylenetriamineplatinum(II) on DNA stability were studied with emphasis on thermodynamic origins of that stability. Oligodeoxyribonucleotide duplexes (15-bp) containing the single, site-specific monofunctional adduct at G-residues of the central sequences TGT/ACA or 5'-AGT/ 5'-ACT were prepared and analyzed by differential scanning calorimetry, temperature-dependent ultraviolet absorption and circular dichroism. The unfolding of the platinated duplexes was accompanied by relatively small unfavorable free energy terms. This destabilization was enthalpic in origin. On the other hand, a relatively large reduction of melting temperature (T-m) was observed as a consequence of the monofunctional adduct in the TGT sequence, whereas T-m due to the adduct in the AGT sequence was reduced only slightly. Effects of adducts of [PtCl(NH3)(3)] Cl or chlorodiethylenetriamineplatinum(II) on DNA stability were studied with emphasis on thermodynamic origins of that stability. Oligodeoxyribonucleotide duplexes (15-bp) containing the single, site-specific monofunctional adduct at G-residues of the central sequences TGT/ACA or 5'-AGT/ 5'-ACT were prepared and analyzed by differential scanning calorimetry, temperature-dependent ultraviolet absorption and circular dichroism. The unfolding of the platinated duplexes was accompanied by relatively small unfavorable free energy terms. This destabilization was enthalpic in origin. On the other hand, a relatively large reduction of melting temperature (T-m) was observed as a consequence of the monofunctional adduct in the TGT sequence, whereas T-m due to the adduct in the AGT sequence was reduced only slightly. (en)
Title	Effects of monofunctional adducts of Platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes Effects of monofunctional adducts of Platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes (en) Vliv monofunkčních aduktů platnatých komplexů na termodynamickou stabilitu a energetiku duplexů DNA (cs)
skos:prefLabel	Effects of monofunctional adducts of Platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes Effects of monofunctional adducts of Platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes (en) Vliv monofunkčních aduktů platnatých komplexů na termodynamickou stabilitu a energetiku duplexů DNA (cs)
skos:notation	RIV/68081707:_____/05:00001331!RIV06-AV0-68081707
http://linked.open.../vavai/riv/strany	1207;1214
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/02/1552), P(GD204/03/H016), P(IAA5004101), P(KJB5004301), P(OC D20.004), Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Hofr, Ctirad Bursová, Vendula
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	519596
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/05:00001331
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA; platinum; cancer (en)
http://linked.open.../riv/klicoveSlovo	DNA cancer platinum
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[59DF8926F675]
http://linked.open...i/riv/nazevZdroje	Biophysical Journal
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Structural biophysics of macromolecules http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20D20.004 Platinated oligonucleotides for selective modulation of gene expression; relations to antisense strategy and development of new drugs. Structure, recognition and biochemistry of DNA modified by antitumor platinum drugs Molecular mechanisms underlying anticancer effects of a new drug BBR3464
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	88
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Hofr, Ctirad Bursová, Vendula
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems
issn	0006-3495
number of pages	8 (xsd:int)

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