About: Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent     Goto   Sponge   NotDistinct   Permalink

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Description
  • Byly studovány můstky vytvořené v DNA enantiomerními komplexy [PtCl2(R,R-2,3-diaminobutane (DAB))] a [PtCl2(S,S-DAB)] mezi sousedními zbytky guaninu v jednom řetězci metodami molekulární biologie, biofyziky a počítačového modelování. Bylo zjištěné, že zatímco strukturní narušení vyvolaná těmito můstky vytvořenými cisplatinou nezávisí na podstatě nukleotidů sousedících s můstkem, strukturní narušení vyvolaná těmito můstky vytvořenými objemnějšími platnatými deriváty závisí. (cs)
  • 1,2-GG intrastrand cross-links formed in DNA by the enantiomeric complexes [PtCl2(R,R-2,3-diaminobutane(DAB))] and [PtCl2(S,S-DAB)] were studied by biophysical methods. Molecular modeling revealed that structure of the cross-links formed at the TGGT sequence was affected by repulsion between the 5,-directed methyl group of the DAB ligand and the methyl group of the 5,-thymine of the TGGT fragment.
  • 1,2-GG intrastrand cross-links formed in DNA by the enantiomeric complexes [PtCl2(R,R-2,3-diaminobutane(DAB))] and [PtCl2(S,S-DAB)] were studied by biophysical methods. Molecular modeling revealed that structure of the cross-links formed at the TGGT sequence was affected by repulsion between the 5,-directed methyl group of the DAB ligand and the methyl group of the 5,-thymine of the TGGT fragment. (en)
Title
  • Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent
  • Chirální rozlišení aduktů DNA vytvořených enantiomerními analogy protinádorově účinné cisplatiny je závislé na sekvenci (cs)
  • Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent (en)
skos:prefLabel
  • Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent
  • Chirální rozlišení aduktů DNA vytvořených enantiomerními analogy protinádorově účinné cisplatiny je závislé na sekvenci (cs)
  • Chiral differentiation of DNA adducts formed by enantiomeric analogues of antitumor cisplatin is sequence-dependent (en)
skos:notation
  • RIV/68081707:_____/05:00001325!RIV06-AV0-68081707
http://linked.open.../vavai/riv/strany
  • 4159;4169
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA305/05/2030), P(IAA5004101), P(IBS5004107), Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 515206
http://linked.open...ai/riv/idVysledku
  • RIV/68081707:_____/05:00001325
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • DNA; platinum; cancer (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [42647391D73E]
http://linked.open...i/riv/nazevZdroje
  • Biophysical Journal
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 88
http://linked.open...iv/tvurceVysledku
  • Brabec, Viktor
  • Malina, Jaroslav
  • Kozelka, J.
  • Delalande, O.
http://linked.open...n/vavai/riv/zamer
issn
  • 0006-3495
number of pages
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