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| Description
| - The effect of the location of the interstrand cross-link formed by trans-diamminedichloroplatinum(H) (transplatin) on the thermal stability and energetics of 15-mer DNA duplex has been investigated. The duplex containing single, site-specific cross-link, thermodynamically equivalent model structures (hairpins) and nonmodified duplexes were characterized by differential scanning calorimetry, temperature-dependent uv absorption, and circular dichroism. The results demonstrate that the formation of the interstrand cross-link of transplatin does not affect pronouncedly thermodynamic stability of DNA: the cross-link induces no marked changes not only in enthalpy, but also in %22reduced%22 (concentration independent) monomolecular transition entropy. These results are consistent with the previous observations that interstrand cross-links of transplatin structurally perturb DNA only to a relatively small extent.
- The effect of the location of the interstrand cross-link formed by trans-diamminedichloroplatinum(H) (transplatin) on the thermal stability and energetics of 15-mer DNA duplex has been investigated. The duplex containing single, site-specific cross-link, thermodynamically equivalent model structures (hairpins) and nonmodified duplexes were characterized by differential scanning calorimetry, temperature-dependent uv absorption, and circular dichroism. The results demonstrate that the formation of the interstrand cross-link of transplatin does not affect pronouncedly thermodynamic stability of DNA: the cross-link induces no marked changes not only in enthalpy, but also in %22reduced%22 (concentration independent) monomolecular transition entropy. These results are consistent with the previous observations that interstrand cross-links of transplatin structurally perturb DNA only to a relatively small extent. (en)
- Byl studován vliv polohy meziřetězcového můstku vytvořeného trans-dimmindichloroplatnatým komplexem (transplatinou) na tepelnou a termodynamickou stabilitu DNA pomocí diferenční skenovací kalorimetrie. Bylo zjištěno, že poloha můstku v duplexu DNA moduluje kooperativitu procesu tání duplexu a následně také tepelnou stabilitu. (cs)
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| Title
| - Thermal stability and energetics of 15-mer DNA duplex interstrand crosslinked by trans-diamminedichloroplatinum(II)
- Tepelná stabilita a energetika duplexu DNA 15 párů bází dlouhého obsahujícího meziřetězcový můstek trans-dimmindichloroplatnatého komplexu (cs)
- Thermal stability and energetics of 15-mer DNA duplex interstrand crosslinked by trans-diamminedichloroplatinum(II) (en)
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| skos:prefLabel
| - Thermal stability and energetics of 15-mer DNA duplex interstrand crosslinked by trans-diamminedichloroplatinum(II)
- Tepelná stabilita a energetika duplexu DNA 15 párů bází dlouhého obsahujícího meziřetězcový můstek trans-dimmindichloroplatnatého komplexu (cs)
- Thermal stability and energetics of 15-mer DNA duplex interstrand crosslinked by trans-diamminedichloroplatinum(II) (en)
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| skos:notation
| - RIV/68081707:_____/05:00001323!RIV06-AV0-68081707
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA305/02/1552), P(GP202/01/D110), P(LZ1K03010), Z(AV0Z50040507)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/05:00001323
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - DNA; interstrand cross-link; transplatin (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Brabec, Viktor
- Hofr, Ctirad
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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