About: Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin

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About: Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The results indicate that structurally different DNA adducts of antitumor trinuclear platinum compound BBR3464 and cisplatin exhibit a different efficiency to affect the binding affinity of the modified DNA to p53 protein. It has been suggested that different structural perturbations induced in DNA by the adducts of BBR3464 and cisplatin produce differential response to p53 protein activation. The results indicate that structurally different DNA adducts of antitumor trinuclear platinum compound BBR3464 and cisplatin exhibit a different efficiency to affect the binding affinity of the modified DNA to p53 protein. It has been suggested that different structural perturbations induced in DNA by the adducts of BBR3464 and cisplatin produce differential response to p53 protein activation. (en) Výsledky ukazují, že strukturně odlišné adukty protinádorově účinného trojjaderného komplexu platiny BBR3464 a cisplatiny vykazují odlišnou účinnost ovlivňovat vazebnou afinitu modifikované DNA k proteinu p53. Bylo navrženo, že odlišná narušení struktury vyvolaná v DNA adukty BBR3464 a cisplatiny jsou signálem pro odlišnou odpověď na aktivaci proteinu p53. (cs)
Title	Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin (en) Odlišné rozlišení DNA modifikované novým protinádorově účinným trojjaderným komplexem platiny BBR3464 a cisplatinou nádorově supresorovým proteinem p53 (cs)
skos:prefLabel	Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin (en) Odlišné rozlišení DNA modifikované novým protinádorově účinným trojjaderným komplexem platiny BBR3464 a cisplatinou nádorově supresorovým proteinem p53 (cs)
skos:notation	RIV/68081707:_____/04:00104638!RIV/2005/AV0/A17005/N
http://linked.open.../vavai/riv/strany	5546;5552
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/02/0734), P(IAA5004101), P(IBS5004009), P(KJB5004301), P(KSK4055109), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	18
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Fojta, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	560575
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/04:00104638
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA; platinum; p53 (en)
http://linked.open.../riv/klicoveSlovo	DNA p53 platinum
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[06BE8902AECB]
http://linked.open...i/riv/nazevZdroje	Nucleic Acids Research
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Physics, chemistry and informatics for biological, ecological and medicinal applications Interactions of tumor suppressor proteins with DNA. Roles of DNA conformation and protein modifications Structure, recognition and biochemistry of DNA modified by antitumor platinum drugs Untraditional therapeutic approaches in oncology Molecular mechanisms underlying anticancer effects of a new drug BBR3464
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Fojta, Miroslav Kašpárková, Jana Farrell, N.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0305-1048
number of pages	7 (xsd:int)

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