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  • Novel distamycin-porphyrin conjugates were synthesized and their interaction with calf thymus DNA was studied. Minor groove binding of the distamycin part of the molecule was confirmed. The porphyrin part of the conjugates exhibited intercalation and the non-specific electrostatic interaction with the phosphate groups of DNA.
  • Novel distamycin-porphyrin conjugates were synthesized and their interaction with calf thymus DNA was studied. Minor groove binding of the distamycin part of the molecule was confirmed. The porphyrin part of the conjugates exhibited intercalation and the non-specific electrostatic interaction with the phosphate groups of DNA. (en)
  • Byly syntetizovány nové konjugáty distamycinu a porfyrinu a byla studována jejich interakce s DNA z telecího brzlíku. Bylo potvrzeno, že distamycinová část konjugátu se váže do malého žlábku DNA. Porfyrinová část vykazuje interkalaci a nespecifickou elektrostatickou interakci s fosfátovými skupinami DNA. (cs)
Title
  • Spectroscopic binding studies of novel fluorescent distamycin derivatives
  • Spektroskopická studie nových fluorescenčních derivátů distamycinu (cs)
  • Spectroscopic binding studies of novel fluorescent distamycin derivatives (en)
skos:prefLabel
  • Spectroscopic binding studies of novel fluorescent distamycin derivatives
  • Spektroskopická studie nových fluorescenčních derivátů distamycinu (cs)
  • Spectroscopic binding studies of novel fluorescent distamycin derivatives (en)
skos:notation
  • RIV/60461373:22340/08:00020630!RIV09-MSM-22340___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA203/06/1038), P(LC512), Z(MSM6046137307)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...dnocenehoVysledku
  • 396460
http://linked.open...ai/riv/idVysledku
  • RIV/60461373:22340/08:00020630
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • distamycin conjugates; DNA; oligonucleotidy; ECD; NMR; UV-VIS; fluorescent (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [BAAEB88D0DE4]
http://linked.open...i/riv/nazevZdroje
  • Tetrahedron Letters
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 49
http://linked.open...iv/tvurceVysledku
  • Král, Vladimír
  • Tkadlecová, Marcela
  • Valík, Martin
  • Foltýnová, J.
http://linked.open...ain/vavai/riv/wos
  • 000253006400028
http://linked.open...n/vavai/riv/zamer
issn
  • 0040-4039
number of pages
http://localhost/t...ganizacniJednotka
  • 22340
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