About: Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is an alkaloid that has been isolated from plants of an Apocynaceae family. It is one of the simplest naturally occurring alkaloids with a planar structure. Over the past decades, ellipticine became a very promising antitumor agent. Interaction with DNA is one of the most studied ellipticine effects on cell division. This phenomenon is not clearly explained so far. In our experiments we studied interaction of ellipticine with single-stranded and double-stranded oligonucleotides by electrochemical methods on mercury electrode. Differential pulse voltammetry was applied for ellipticine (Elli) and CA peak detection. Square wave voltammetry was applied for G peak detection. The effect of the interaction time and ellipticine concentrations on interactions of ellipticine with single- and double-stranded oligonucleotides was tested too. Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is an alkaloid that has been isolated from plants of an Apocynaceae family. It is one of the simplest naturally occurring alkaloids with a planar structure. Over the past decades, ellipticine became a very promising antitumor agent. Interaction with DNA is one of the most studied ellipticine effects on cell division. This phenomenon is not clearly explained so far. In our experiments we studied interaction of ellipticine with single-stranded and double-stranded oligonucleotides by electrochemical methods on mercury electrode. Differential pulse voltammetry was applied for ellipticine (Elli) and CA peak detection. Square wave voltammetry was applied for G peak detection. The effect of the interaction time and ellipticine concentrations on interactions of ellipticine with single- and double-stranded oligonucleotides was tested too. (en)
Title	Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides (en)
skos:prefLabel	Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides (en)
skos:notation	RIV/00216305:26620/14:PU111498!RIV15-MSM-26620___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(GAP301/10/0356)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Babula, Petr Trnková, Libuše Hynek, David Adam, Vojtěch Kizek, René Tmejová, Kateřina Krejčová, Ludmila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	14119
http://linked.open...ai/riv/idVysledku	RIV/00216305:26620/14:PU111498
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Adsorptive transfer stripping technique, DNA, differential pulse voltammetry, ellipticine, hetero-nucleotides, intercalation, square wave voltammetry, cancer, therapy (en)
http://linked.open.../riv/klicoveSlovo	ellipticine intercalation square wave voltammetry DNA cancer therapy Adsorptive transfer stripping technique hetero-nucleotides differential pulse voltammetry
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[628D7C17DE66]
http://linked.open...i/riv/nazevZdroje	Anti-Cancer Agents in Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Study of contribution of different DNA-damaging mechanisms to toxicity of cytostatics to human chemosensitive and chemoresistant neuroblastomas
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Babula, Petr Eckschlager, Tomáš Hynek, David Kizek, René Krejčová, Ludmila Stiborová, Marie Trnková, Libuše Tmejová, Kateřina
http://linked.open...ain/vavai/riv/wos	000331462800016
issn	1871-5206
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	26620

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