About: Fullerene as a transporter for doxorubicin investigated by analytical methods and in vivo imaging

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About: Fullerene as a transporter for doxorubicin investigated by analytical methods and in vivo imaging Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Carbon nanomaterials, including fullerenes, exhibit not only unique structure and electronic properties but also a significant potential to serve as radical scavengers and/or anti-oxidants. Their conjugation with anticancer drugs such as doxorubicin (DOX) may help to balance severe negative side effects of these cytostatics and also improve the delivery of the drug taking advantage of the enhanced cellular uptake, selectivity to cancer cells, and pH regulated release. In this study, the fullerene (C60) surface was oxidized by concentrated nitric acid, which enabled simple DOX–fullerene conjugation based on stacking and hydrophilic interactions with carboxylic groups. The strength of this noncovalent binding is pH dependent. At a low pH, the amino group of DOX is protonated, however at a higher pH, the amino group is deprotonated, resulting in stronger hydrophobic interactions with the fullerene walls. CE and HPLC were employed for characterization of resulting complexes. The cell toxicity of the con Carbon nanomaterials, including fullerenes, exhibit not only unique structure and electronic properties but also a significant potential to serve as radical scavengers and/or anti-oxidants. Their conjugation with anticancer drugs such as doxorubicin (DOX) may help to balance severe negative side effects of these cytostatics and also improve the delivery of the drug taking advantage of the enhanced cellular uptake, selectivity to cancer cells, and pH regulated release. In this study, the fullerene (C60) surface was oxidized by concentrated nitric acid, which enabled simple DOX–fullerene conjugation based on stacking and hydrophilic interactions with carboxylic groups. The strength of this noncovalent binding is pH dependent. At a low pH, the amino group of DOX is protonated, however at a higher pH, the amino group is deprotonated, resulting in stronger hydrophobic interactions with the fullerene walls. CE and HPLC were employed for characterization of resulting complexes. The cell toxicity of the con (en)
Title	Fullerene as a transporter for doxorubicin investigated by analytical methods and in vivo imaging Fullerene as a transporter for doxorubicin investigated by analytical methods and in vivo imaging (en)
skos:prefLabel	Fullerene as a transporter for doxorubicin investigated by analytical methods and in vivo imaging Fullerene as a transporter for doxorubicin investigated by analytical methods and in vivo imaging (en)
skos:notation	RIV/00216305:26620/14:PU109895!RIV15-MSM-26620___
http://linked.open...avai/riv/aktivita	O P
http://linked.open...avai/riv/aktivity	O, P(ED1.1.00/02.0068)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Konečná, Romana Hynek, David Beklová, Miroslava Kizek, René Zítka, Ondřej Krejčová, Ludmila Komínková, Markéta Kopel, Pavel Nguyen, Hoai Viet
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	17624
http://linked.open...ai/riv/idVysledku	RIV/00216305:26620/14:PU109895
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Clinical analysis, Doxorubicin, Drug delivery, Embryo, Fullerene, Nanomedicine (en)
http://linked.open.../riv/klicoveSlovo	Clinical analysis Doxorubicin Fullerene Embryo Drug delivery Nanomedicine
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[0F1F84635959]
http://linked.open...i/riv/nazevZdroje	Electrophoresis
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	35
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Beklová, Miroslava Hynek, David Kizek, René Krejčová, Ludmila Zítka, Ondřej Blažková, Iva Kopel, Pavel Komínková, Markéta Nguyen, Hoai Viet Chudobová, Dagmar Konečná, Romana
issn	0173-0835
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	26620

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