About: Electrochemical Behaviour of Native and Denatured B-Sheet Breaker Prion Protein

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Prion diseases are fatal neurodegenerative and infectious disorders of humans and animals, characterized by structural transition of the host-encoded cellular prion protein (PrPC) into the aberrantly folded pathologic isoform PrPSc. The conformation change, from the a-helix in the natural protein form (PrPc) to the b-sheet of the modified protein form (PrPSc), significantly influence the protein function. The mutated form (PrPSc) is extremely resistant to the cell degradation processes and may bind other PrPc molecules inducing the conformation change to the PrPSc. The insufficiency of the physiological PrPc and toxic incidence of PrPSc participate on the genesis of prion neurodegenerative diseases. The main aim of this study was to suggest electrochemical methods for detection of b-sheet breaker prion protein. For this purpose cyclic voltammetry (CV), differential pulse voltammetry (DPV), differential pulse voltammetry Brdicka reaction and chronopotentiometric stripping analysis (CPSA) were used. Pri Prion diseases are fatal neurodegenerative and infectious disorders of humans and animals, characterized by structural transition of the host-encoded cellular prion protein (PrPC) into the aberrantly folded pathologic isoform PrPSc. The conformation change, from the a-helix in the natural protein form (PrPc) to the b-sheet of the modified protein form (PrPSc), significantly influence the protein function. The mutated form (PrPSc) is extremely resistant to the cell degradation processes and may bind other PrPc molecules inducing the conformation change to the PrPSc. The insufficiency of the physiological PrPc and toxic incidence of PrPSc participate on the genesis of prion neurodegenerative diseases. The main aim of this study was to suggest electrochemical methods for detection of b-sheet breaker prion protein. For this purpose cyclic voltammetry (CV), differential pulse voltammetry (DPV), differential pulse voltammetry Brdicka reaction and chronopotentiometric stripping analysis (CPSA) were used. Pri (en)
Title	Electrochemical Behaviour of Native and Denatured B-Sheet Breaker Prion Protein Electrochemical Behaviour of Native and Denatured B-Sheet Breaker Prion Protein (en)
skos:prefLabel	Electrochemical Behaviour of Native and Denatured B-Sheet Breaker Prion Protein Electrochemical Behaviour of Native and Denatured B-Sheet Breaker Prion Protein (en)
skos:notation	RIV/00216305:26620/12:PU99117!RIV13-AV0-26620___
http://linked.open...avai/predkladatel	Středoevropský technologický institut
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(GAP102/11/1068), P(IAA401990701), P(KAN208130801)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Ryvolová, Markéta Hynek, David Adam, Vojtěch Hubálek, Jaromír Kizek, René Šobrová, Pavlína
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Vysoké učení technické v Brně / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	133855
http://linked.open...ai/riv/idVysledku	RIV/00216305:26620/12:PU99117
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Prion protein (PrPSc – scrapie), Adsorptive transfer stripping technique, cyclic voltammetry (CV), differential pulse voltammetry (DPV), Brdicka reaction, Chronopotenciometric stripping analysis (CPSA) (en)
http://linked.open.../riv/klicoveSlovo	Adsorptive transfer stripping technique Chronopotenciometric stripping analysis (CPSA) Prion protein (PrPSc – scrapie) cyclic voltammetry (CV) differential pulse voltammetry (DPV) Brdicka reaction
http://linked.open...odStatuVydavatele	RS - Srbská republika
http://linked.open...ontrolniKodProRIV	[BC0052F4FF82]
http://linked.open...i/riv/nazevZdroje	INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Study of binding of platinum cytostatics to DNA structure; Influence of metallothionein New design and exploiting nanobiosensors and nanosensors to target medicine (NANOSEMED) Nano-Electro-Bio-Tools for Biochemical and Molecularly-Biological Studies of Eukaryotic Cells (NanoBioTECell)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Hubálek, Jaromír Hynek, David Kizek, René Vaculovičová, Markéta Šobrová, Pavlína
http://linked.open...ain/vavai/riv/wos	000302730000003
issn	1452-3981
number of pages	15 (xsd:int)
http://localhost/t...ganizacniJednotka	26620

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