About: Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice

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rdfs:seeAlso	http://mct.aacrjournals.org/content/13/4/812.long
Description	The Wnt signaling pathway is required during embryonic development and for the maintenance of homeostasis in adult tissues. However, aberrant activation of the pathway is implicated in a number of human disorders, including cancer of the gastrointestinal tract, breast, liver, melanoma, and hematologic malignancies. In this study, we identified monensin, a polyether ionophore antibiotic, as a potent inhibitor of Wnt signaling. The inhibitory effect of monensin on the Wnt/beta-catenin signaling cascade was observed in mammalian cells stimulated with Wnt ligands, glycogen synthase kinase-3 inhibitors, and in cells transfected with beta-catenin expression constructs. Furthermore, monensin suppressed the Wnt-dependent tail fin regeneration in zebrafish and Wnt- or beta-catenin-induced formation of secondary body axis in Xenopus embryos. In Wnt3a-activated HEK293 cells, monensin blocked the phoshorylation of Wnt coreceptor low-density lipoprotein receptor related protein 6 and promoted its degradation. The Wnt signaling pathway is required during embryonic development and for the maintenance of homeostasis in adult tissues. However, aberrant activation of the pathway is implicated in a number of human disorders, including cancer of the gastrointestinal tract, breast, liver, melanoma, and hematologic malignancies. In this study, we identified monensin, a polyether ionophore antibiotic, as a potent inhibitor of Wnt signaling. The inhibitory effect of monensin on the Wnt/beta-catenin signaling cascade was observed in mammalian cells stimulated with Wnt ligands, glycogen synthase kinase-3 inhibitors, and in cells transfected with beta-catenin expression constructs. Furthermore, monensin suppressed the Wnt-dependent tail fin regeneration in zebrafish and Wnt- or beta-catenin-induced formation of secondary body axis in Xenopus embryos. In Wnt3a-activated HEK293 cells, monensin blocked the phoshorylation of Wnt coreceptor low-density lipoprotein receptor related protein 6 and promoted its degradation. (en)
Title	Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice (en)
skos:prefLabel	Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice (en)
skos:notation	RIV/00216224:14740/14:00075743!RIV15-MSM-14740___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(FR-TI4/802), P(GAP305/12/2347), P(LM2011022), P(LO1220), S
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Zdráhal, Zbyněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Středoevropský technologický institut
http://linked.open...dnocenehoVysledku	30344
http://linked.open...ai/riv/idVysledku	RIV/00216224:14740/14:00075743
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	BETA-CATENIN; CYCLE ARREST; COLON-CANCER; CARCINOMA-CELLS; LEUKEMIA-CELLS; IN-VIVO; APOPTOSIS; ACTIVATION; APC; GENES (en)
http://linked.open.../riv/klicoveSlovo	CARCINOMA-CELLS CYCLE ARREST LEUKEMIA-CELLS COLON-CANCER APOPTOSIS ACTIVATION IN-VIVO BETA-CATENIN GENES APC
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[06514E1E5A2A]
http://linked.open...i/riv/nazevZdroje	Molecular Cancer Therapeutics
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...vavai/riv/projekt	CZ-OPENSCREEN: National Infrastructure for Chemical Biology Central european institute of technology Molecular mechanisms of the tumor suppressor function of the HIC1 gene CZ-OPENSCREEN: National infrastructure for chemical biology *Development of new chemical compounds with anti-tumor activities or use in regenerative medicine
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	13
http://linked.open...iv/tvurceVysledku	Bartůněk, Petr Jindřich, Jindřich Kříž, Vítězslav Tůmová, Lucie Zdráhal, Zbyněk Kořínek, Vladimír Krausová, Michaela Vojtěchová, Martina Šloncová, Eva Machoňová, Olga Stančíková, Jitka Pombinho, Antonio Gradl, Dietmar Horázná, Monika
http://linked.open...ain/vavai/riv/wos	000334342300005
issn	1535-7163
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1158/1535-7163.MCT-13-0625
http://localhost/t...ganizacniJednotka	14740

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