About: Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1 epsilon and Frizzled5

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About: Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1 epsilon and Frizzled5 Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.ncbi.nlm.nih.gov/pubmed/24993822
Description	Background: Phosphorylation of Dishevelled (Dvl) by casein kinase 1E (CK1E) is a key event in Wnt signal transduction. Results: Dvl3 residues phosphorylated by CK1E were identified by proteomics and analyzed functionally. Conclusion: Individual phosphorylation events control different aspects of Dvl biology. Significance: CK1E and Fzd5, a Wnt receptor, act on Dvl via distinct mechanism, suggesting that CK1E is not directly downstream of Frizzled5. Dishevelled-3 (Dvl3), a key component of the Wnt signaling pathways, acts downstream of Frizzled (Fzd) receptors and gets heavily phosphorylated in response to pathway activation by Wnt ligands. Casein kinase 1E (CK1E) was identified as the major kinase responsible for Wnt-induced Dvl3 phosphorylation. Currently it is not clear which Dvl residues are phosphorylated and what is the consequence of individual phosphorylation events. Background: Phosphorylation of Dishevelled (Dvl) by casein kinase 1E (CK1E) is a key event in Wnt signal transduction. Results: Dvl3 residues phosphorylated by CK1E were identified by proteomics and analyzed functionally. Conclusion: Individual phosphorylation events control different aspects of Dvl biology. Significance: CK1E and Fzd5, a Wnt receptor, act on Dvl via distinct mechanism, suggesting that CK1E is not directly downstream of Frizzled5. Dishevelled-3 (Dvl3), a key component of the Wnt signaling pathways, acts downstream of Frizzled (Fzd) receptors and gets heavily phosphorylated in response to pathway activation by Wnt ligands. Casein kinase 1E (CK1E) was identified as the major kinase responsible for Wnt-induced Dvl3 phosphorylation. Currently it is not clear which Dvl residues are phosphorylated and what is the consequence of individual phosphorylation events. (en)
Title	Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1 epsilon and Frizzled5 Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1 epsilon and Frizzled5 (en)
skos:prefLabel	Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1 epsilon and Frizzled5 Functional Analysis of Dishevelled-3 Phosphorylation Identifies Distinct Mechanisms Driven by Casein Kinase 1 epsilon and Frizzled5 (en)
skos:notation	RIV/00216224:14310/14:00074125!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(EE2.3.20.0042), P(GA204/09/0498), P(GP13-31488P), P(LM2011020), S, Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	34
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Trantírek, Lukáš Bernatík, Ondřej Bryja, Vítězslav Zdráhal, Zbyněk Nováková, Kateřina Červenka, Igor Ganji, Sri Ranjani
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	17651
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/14:00074125
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	PLANAR CELL POLARITY; BETA-CATENIN; WNT/BETA-CATENIN; PDZ DOMAIN; I-EPSILON; WNT PATHWAY; PROTEIN; DROSOPHILA; DVL; FAMILY (en)
http://linked.open.../riv/klicoveSlovo	PDZ DOMAIN PROTEIN PLANAR CELL POLARITY BETA-CATENIN DVL I-EPSILON DROSOPHILA WNT PATHWAY FAMILY WNT/BETA-CATENIN
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[92A11916B5B9]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology CEITEC – open access Dynamics of proteins interacting with Dishevelled and their importance for Wnt signalling Internationalisation of the Structural Biology Research Programme with Emphasis on New Directions in R&D Vliv posttranslačních modifikací Dishevelled na Wnt signální dráhy
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	289
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Zdráhal, Zbyněk Červenka, Igor Ganji, Sri Ranjani Trantírek, Lukáš Bernatík, Ondřej Schambony, Alexandra Schille, Carolin Šedová, Kateřina
http://linked.open...ain/vavai/riv/wos	000341505000023
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	0021-9258
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1074/jbc.M114.590638
http://localhost/t...ganizacniJednotka	14310

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