About: Application of Positron Emission Tomography to aerosol transport research in a model of human lungs

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.epj-conferences.org/articles/epjconf/pdf/2013/06/epjconf_efm2013_01060.pdf
Description	Positron Emission Tomography (PET) is a convenient method for measurement of aerosol deposition in complex models of lungs. It allows not only the evaluation of regional deposition characteristics but also precisely detects deposition hot spots. The method is based on a detection of a pair of annihilation photons moving in opposite directions as a result of positron – electron interaction after the positron emission decay of a suitable radioisotope. Liquid di(2-ethylhexyl) sebacate (DEHS) particles tagged with fluorine-18 as a radioactive tracer were generated by condensation monodisperse aerosol generator. Aerosol deposition was measured for three different inhalation flowrates and for two sizes of particles. Combination of PET with Computed Tomography (CT) in one device allowed precise localisation of particular segments of the model. The results proved correlation of deposition efficiency with Stokes number, which means that the main deposition mechanism is inertial impaction. As a next task the methodology for tagging the solid aerosol particles with radioactive tracer will be developed and deposition of porous and fiber aerosols will be measured. Positron Emission Tomography (PET) is a convenient method for measurement of aerosol deposition in complex models of lungs. It allows not only the evaluation of regional deposition characteristics but also precisely detects deposition hot spots. The method is based on a detection of a pair of annihilation photons moving in opposite directions as a result of positron – electron interaction after the positron emission decay of a suitable radioisotope. Liquid di(2-ethylhexyl) sebacate (DEHS) particles tagged with fluorine-18 as a radioactive tracer were generated by condensation monodisperse aerosol generator. Aerosol deposition was measured for three different inhalation flowrates and for two sizes of particles. Combination of PET with Computed Tomography (CT) in one device allowed precise localisation of particular segments of the model. The results proved correlation of deposition efficiency with Stokes number, which means that the main deposition mechanism is inertial impaction. As a next task the methodology for tagging the solid aerosol particles with radioactive tracer will be developed and deposition of porous and fiber aerosols will be measured. (en)
Title	Application of Positron Emission Tomography to aerosol transport research in a model of human lungs Application of Positron Emission Tomography to aerosol transport research in a model of human lungs (en)
skos:prefLabel	Application of Positron Emission Tomography to aerosol transport research in a model of human lungs Application of Positron Emission Tomography to aerosol transport research in a model of human lungs (en)
skos:notation	RIV/00209805:_____/13:#0000599!RIV15-MSM-00209805
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ED2.1.00/03.0101), P(GAP105/11/1339), P(ME09030), S
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Adam, Jan
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykův onkologický ústav
http://linked.open...dnocenehoVysledku	123369
http://linked.open...ai/riv/idVysledku	RIV/00209805:_____/13:#0000599
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	aerosol transport; positron emission tomography; human lung model (en)
http://linked.open.../riv/klicoveSlovo	aerosol transport human lung model positron emission tomography
http://linked.open...ontrolniKodProRIV	[70FF387F066C]
http://linked.open...v/mistoKonaniAkce	Hradec Králové
http://linked.open...i/riv/nazevZdroje	EPJ Web of Conferences
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Regional Centre for Applied Molecular Oncology (RECAMO) Porous particle-laden turbulent and laminar oscillating and steady flow in multiple branching Optimazation of therapeutic inhaled aerosols targeted delivery
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Adam, Jan
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open...ain/vavai/riv/wos	000319932200060
http://linked.open.../riv/zahajeniAkce	2013-01-01 (xsd:date)
issn	2100-014X
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1051/epjconf/20134501060
http://purl.org/ne...btex#hasPublisher	E D P SCIENCES
https://schema.org/isbn	978-80-7372-912-7

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