About: Oligonucleotide DNA Micro-Array Synthesis Quality     Goto   Sponge   NotDistinct   Permalink

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Description
  • The aim of the project is to improve the quality of DNA microarrays produced by ink jet synthesizer and microarrayer. This will be achieved by means of designing and incorporating a real time sensor of the nozzle flow into the ink jet synthesizer and microarrayer and molecular-analytical output control. The nozzle flow sensor will monitor the occurrence, the position and the shape of the printed beads. After the nozzle gets clogged, the sensor will send a signal to the printing head and another nozzle will print the nucleotide on the effected spot. The molecular-analytical output control will analyze the quality of the final DNA microarrays by checking the density and oligonucleotide sequences and compare them to market-established products. Consequently, the errors in the oligonucleotide sequence that occur due to a random clogging of the nozzles will be eliminated. Moreover, the production process will increase in speed and become more effective as the double printing currently applied will no long (en)
  • Cílem projektu OLIGOSYNT je inovace výroby DNA čipů vývojem vysoce vyspělé technologie vizuální kontroly komunikující s robotem v reálném čase a výstupní analytické kontroly a tím zvýšit kvalitu, produktivitu a lépe konkurovat zavedeným výrobcům z USA.
Title
  • Oligonucleotide DNA Micro-Array Synthesis Quality (en)
  • Kvalita syntézy oligonukleotidového DNA - čipu
skos:notation
  • OE09009
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  • DNA Microarray; ink jet technology; ink jet synthesizer and microarrayer; real time sensor; nozzle clogging; quality of DNA Microarray; oligonucleotide synthesis; oligonucleotide analysis; DNA sequencing; DNA Microarray analysis; hybridization (en)
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  • The outcome of the project OLIGOSYNT is a new functional design of a scanning device for acquisition of 3D patterns, software for image analysis of DNA microarrays, two chapters in foreign professional books and a professional article. The system of visual quality control was verified in an industrial unit, the quality control system using real samples of microarrays. (en)
  • Výsledkem řešení projektu OLIGOSYNT je nový funkční vzorek snímacího zařízení pro snímání 3D tvarů, software pro analýzu obrazu DNA čipů, dvě kapitoly v odborných zahraničních knihách a odborný článek. Systém vizuální kontroly kontroly byl ověřen na průmyslové jednotce, systém kontroly kvality na reálných vzorcích microarrays. (cs)
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http://linked.open.../cep/klicoveSlovo
  • DNA Microarray
  • DNA sequencing
  • DNA Microarray analysis
  • ink jet synthesizer and microarrayer
  • ink jet technology
  • nozzle clogging
  • oligonucleotide analysis
  • oligonucleotide synthesis
  • quality of DNA Microarray
  • real time sensor
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