About: Application of DNA methylation arrays for assessment of aberrantly methylated genes in MDS and AML patients     Goto   Sponge   NotDistinct   Permalink

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  • Hematological malignancies, such as other malignancies, have specific epigenetic alterations of tumor suppressor genes, genes involved in differentiation, apoptosis, metastasis etc. The alterations of gene promoter methylation lead to uncontrolled proliferation of leukemic cells and malignant transformation. The DNA methylation changes can be used to detect leukemic cells in peripheral blood. We will examine the DNA methylation status of a wide spectrum of genes by the use of DNA methylation PCR arrays which allows us to observe multiple changes in gene methylation profile. These arrays are convenient for a more detail insight of epigenetic modifications occurring during the malignant transformation of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). We will choose the panel of the most promising genes based on our previous results from cultivation with demethylating agents such as Decitabine and on recently published data from genome-wide methylation studies. We will assess the (en)
  • Na základě našich předběžných výsledků a údajů z literatury chceme získat nové informace o epigenetické regulaci leukemogeneze AML a progrese MDS a tím přispět k individualizaci a zvýšení účinnosti léčby AML a MDS. (max.255 znaků)
Title
  • Application of DNA methylation arrays for assessment of aberrantly methylated genes in MDS and AML patients (en)
  • Studium aberantně metylovaných genů u pacientů s MDS a AML pomocí DNA metylačních arrayí.
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  • OC10042
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  • hypermethylation; tumor suppressor genes; epigenetics; minimal residual disease; demethylation drugs; DNA methylation array; MDS; AML (en)
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  • DNA methylation status of selected genes was correlated with patients' prognosis and mutational status of DNMT3A gene. We found influence of DNA methylation on overall survival and incidence of relapses as well as relationship between DNMT3A mutations and DNA methylation. Further we performed whole genome bisulfite sequencing and expression profiling to reveal the complex role of DNA methylation. (en)
  • Metylační status vybraných genů byl korelován s prognózou onemocnění a s mutačním stavem genu DNMT3A. Nalezli jsme souvislost mezi metylací DNA těchto genů, celkovým přežitím a incidencí relapsů. Dále jsme detekovali nižší metylací DNA u pacientů s mutovaným genem DNMT3A. Pro komplexní pohled na změny v metylaci DNA bylo provedeno celogenomové bisulfitové sekvenování a expresní profilování. (cs)
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  • hypermethylation
  • epigenetics
  • DNA methylation array
  • MDS
  • demethylation drugs
  • minimal residual disease
  • tumor suppressor genes
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