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  • Characterization of metalloproteins important in cancer their interactions with DNA (en)
  • Charakterizace metaloproteinů významných v rakovině, zejména nádorového supresoru p53 a metalothioneinů. Bude zkoumána vazba p53 na lineární a nadšroubovicové DNA a navrženy nové metody anylýzy těchto proteinů.
Title
  • Characterization of metalloproteins important in cancer their interactions with DNA (en)
  • Charakterizace metaloproteinů významných v rakovině a jejich interakce s DNA
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  • OC D21.002
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  • metalloproteins; important cancer; DNA (en)
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  • 7 publikací, 1 kapitola v knize, 1 kniha. Byly navrženy elektrochemické metody analýzy bílkovin a nové přístupy výzkumu interakci DNA-protein. Bylo zjištěno, že nádorový supresor protein p53 (obs. Zn) se preferenčně váže na cílovou sekvenci v superheliká (cs)
  • 7 papers, 1 book chapter, 1 book. Electrochemical methods of protein analysis and new approaches in studies of DNA-protein interactions were proposed. It was found that zinc-containing tumor suppressor protein p53 binds preferentially to consensus seque (en)
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  • metalloproteins
  • important cancer
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