About: The role of neuroactive steroids in etiopathogenesis of mood and anxiety disorders     Goto   Sponge   NotDistinct   Permalink

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Description
  • This research is to quantify a broad spectrum of steroids in patients with anxiety and mood disorders (AMD) and to gain data about the pathophysiological importance and clinical relevance of neuroactive and neuroprotective steroids in AMD patients, which will be valuable for the comprehension of AMD pathophysiology and for the development of novel therapeutic strategies. It is also to complete models predicting the risk of AMD manifestation from laboratory and clinical data with the use of multivariate analysis. Based on clinical and metabolomics data, the completion of a differential diagnostics in individual CNS disturbances will be attempted. (en)
  • Stanovit široké spektrum steroidů u pacientů s úzkostnými a depresivními poruchami (AMD) a získat údaje o patofyziologickém významu a klinické relevanci neuroaktivních a neuroprotektivních steroidů u pacientů s AMD, což bude přínosné pro pochopení patofyziologie AMD a vývoj nových strategií léčby. Navrhnout modely predikující riziko vzniku AMD z laboratorních a anamnestických dat s využitím multikomponentní analýzy. Na základě klinických a metabolomických dat se pokusit o diferenciální diagnostiku jednotlivých poruch CNS.
Title
  • The role of neuroactive steroids in etiopathogenesis of mood and anxiety disorders (en)
  • Úloha neuroaktivních steroidů v etiopatogenezi afektivních a úzkostných poruch
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  • NT13890
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  • anxiety disorder; mood disorder; steroids; metabolomics; GC MS; multivariate prediction models (en)
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  • anxiety disorder
  • metabolomics
  • GC MS
  • mood disorder
  • steroids
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