About: The implication of genomic changes in pathogenesis of low grade brain gliomas and their correlation with H-MRSI spectroscopy and histological analysis     Goto   Sponge   NotDistinct   Permalink

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  • Prospective a retrospective molecular cytogenetic analysis of the tumor cell genome in patients with low-grade gliomas. Detection of specific chromosomal aberrations using I-FISH and MLPA, identification of recurrent changes in DNA sequence content using SNP array, an assessment of their prognostic significance. Based on the correlation of HMRSI spectroscopy, molecular cytogenetic and histological findigs, the probability of malignant transformation of low-grade glioma into anaplastic astrocytoma will be estimated. Identification of genetic changes directly related to the progression of low-grade gliomas. (en)
  • Prospetktivní a retrospektivní molekulárně cytogenetická analýza genomu nádorových buněk u nemocných s low-grade gliomy. Detekce specifických genomových aberací metodou I-FISH a MLPA, identifikace rekurentních změn v obsahu DNA sekvencí metodou SNP array, zhodnocení jejich prognostického významu. Stanovení predikce maligního zvratu low-grade gliomu v anaplastický astrocytom na základě korelace nálezů HMRSI spektroskopie s výsledky molekulárně cytogenetických analýz a histologie. Identifikace genetických a epigenetických změn s přímým vztahem k progresi low-grade gliomů.
Title
  • The implication of genomic changes in pathogenesis of low grade brain gliomas and their correlation with H-MRSI spectroscopy and histological analysis (en)
  • Význam genomových změn v pathogenezi nízkostupňových gliomů a korelace s HMRSI spektroskopií a histologickou analýzou.
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  • NT13212
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  • low-grade gliomas; genetic aberrations; molecular cytogenetic analysis; I-FISH; SNP array; HMRSI spectrosomy; histology; tumor progression (en)
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  • histology
  • HMRSI spectrosomy
  • I-FISH
  • SNP array
  • genetic aberrations
  • molecular cytogenetic analysis
  • low-grade gliomas
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