About: The role of abnormalities in the metabolic pathway of cytochrome P450 in the pathophysiology of hypertensive organ damage: posibilities of prevention and ragression of glomerulosclerosis.     Goto   Sponge   NotDistinct   Permalink

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  • The role of arachidonic acid metabolites in the pathophysiology of hypertensive organ damage will be studied via targeted inhibition of the enzyme catalyzing conversion of vasodilatory epoxyeicosatrienoic acids and via inhibition of vasoconstrictive 20-hydroxyeicosatetraenoic acids production. (en)
  • Objasnění úlohy metabolitů kyseliny arachidonové v patofyziologii hypertenzního orgánového poškození pomocí cílené inhibice enzymu katalyzujícího přeměnu vazodilatačních epoxyeikosatrienových kyselin (EETs) a pomocí inhibice tvorby vazokonstrikčních 20-hydroxyeikosatetraenových kyselin (20-HETE).
Title
  • The role of abnormalities in the metabolic pathway of cytochrome P450 in the pathophysiology of hypertensive organ damage: posibilities of prevention and ragression of glomerulosclerosis. (en)
  • Úloha abnormalit v metabolické cestě cytochromu P450 v patofyziologii hypertenzního orgánového poškození: možnosti prevence a regrese glomerulosklerózy.
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  • NT12171
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  • hypertension; renal failure; cytochrome P450 metabolites; renin-angiotensin system; hypertension treatment (en)
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  • hypertension
  • cytochrome P450 metabolites
  • renal failure
  • renin-angiotensin system
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