About: Role of the host-dependent factors in prediction of antiviral treatment response in chronic hepatitis C     Goto   Sponge   NotDistinct   Permalink

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  • We shall validate the significance of the polymorphism -764G/C in the interferon gamma gene promoter and polymorphisms in IL28B gene in prediction of treatment response in chronic hepatitis C with peginterferon alpha and ribavirin in a cohort of patients treated in the past. In the group of patients recently starting antiviral treatment of chronic hepatitis C, we shall asses the expression of the interferon gamma gene, interferon lambda 3 and a set of of interferon sensitive genes USP18, ISG15, IFI27, IFI-6-16 and CXCL9 in the liver tissue and peripheral blood mononuclear cells before treatment. The assessment of gene expression will be monitored in peripheral blood mononuclear cells within the early treatment period . (en)
  • Bude provedena validace významu polymorfizmu -764G/C v promotoru genu pro interferon gamma a polymorfismů v genu IL28B pro predikci úspěchu léčby chronické hepatitidy C peginterferonem alfa a ribavirinem na souboru léčených pacientů. U pacientů nově indikovaných k protivirové léčbě chronické hepatitidy C bude stanovena exprese genu pro interferon gamma, interferon lambda 3 a interferon senzitivních genů USP18, ISG 15, IFI27, IFI-6-16 a CXCL9 před zahájením léčby v játrech a v mononukleárech z periferní krve. Vyšetření v mononukleárech bude opakováno v časné fázi léčby.
Title
  • Role of the host-dependent factors in prediction of antiviral treatment response in chronic hepatitis C (en)
  • Úloha faktorů hostitele v odpovědi na protivirovou léčbu chronické hepatitidy C
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  • NT11235
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  • Chronic hepatitis C; treatment; interferon-sensitive genes (en)
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  • treatment
  • Chronic hepatitis C
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